Effect of Smoking Cessation on Clinical and Microbiological Outcomes of the Non-surgical Periodontal Therapy (EsCAPE2)

NCT02744417 NA COMPLETED

The aim of this prospective interventional study is to verify the efficacy of smoking cessation on clinical and microbiological outcomes of non-surgical periodontal therapy of chronic periodontitis patients. Smokers willing to quit received periodontal treatment and concurrent smoking cessation therapy. Periodontal maintenance was performed every 3 months. A single calibrated examiner, blinded to smoking status, assessed periodontal clinical outcomes and applied a structured questionnaire in order to collect demographic and behavioural information. Further, expired carbon monoxide concentration were measured with a monoximeter. A pooled subgingival plaque sample was collected from the deepest periodontal pocket from each participant. The presence and quantification of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola were determined using (RT-PCR).

Details

Lead sponsor	Claudio Mendes Pannuti
Phase	NA
Status	COMPLETED
Enrolment	63
Start date	2010-08
Completion	2014-03

Conditions

• Periodontitis

Interventions

• Smoking cessation counseling
• Non-surgical periodontal therapy
• Nicotine replacement therapy
• bupropion hydrochloride
• Varenicline

Primary outcomes

• Change in Clinical Attachment Level — baseline - 12 months
  Change in Clinical Attachment Level (millimeters) after 12 months