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NCT02743585: RABbIT
Impact of Rapid Pathogen Identification From Blood Cultures (RABbIT)
NA trial testing Filmarray Blood Culture ID (BCID) panel in Bacteremia in 832 participants. Status unknown.
2 July 2019
Quick facts
| Lead sponsor | Tan Tock Seng Hospital |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | diagnostic |
| Enrollment | 832 |
| Start date | 20 March 2017 |
| Primary completion | 2 July 2019 |
| Estimated completion | 2 July 2020 |
| Sites | 1 location across Singapore |
Drugs / interventions tested
- Filmarray Blood Culture ID (BCID) panel
- Rosco Diagnostica ESBL/carbapenemase screen kit
Conditions studied
- Bacteremia — all drugs for Bacteremia →
- Sepsis — all drugs for Sepsis →
- Fungemia — all drugs for Fungemia →
- Blood Stream Infection — all drugs for Blood Stream Infection →
Sponsor
Tan Tock Seng Hospital
Who can join
Adults 21 to 103, any sex, with Bacteremia or Sepsis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Septic shock carries high mortality, which may be exacerbated by inappropriate initial therapy. Inappropriate therapy may result from unanticipated antimicrobial resistance. Conversely, positive blood cultures may result from contamination, leading to unnecessary therapy and procedures and possibly prolonged hospitalization. Clinicians may also resort to broad spectrum antimicrobials and be hesitant to de-escalate while awaiting susceptibility results. The investigators hypothesize that rapid identification of pathogens and antimicrobial resistance will ameliorate the above problems and improve time to optimal therapy, avoid unnecessary therapy and ultimately improve patient outcomes. While there are a number of in-vitro and uncontrolled clinical studies, there is a paucity of well-designed clinical trials objectively examining the real-world clinical and health-economic impact of such technology. To date only one randomised trial has been performed in the US (ClinicalTrials.gov NCT01898208), at a setting with low endemic rates of antimicrobial resistance. This is a companion study to NCT01898208. The investigators aim to study the clinical impact and cost-effectiveness of a strategy for rapid pathogen and resistance detection in a setting with a moderate to high levels of antimicrobial resistance.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
An Update on Recent Clinical Trial Data in Bloodstream Infection.
Stewart AG, Simos P, Sivabalan P, Escolà-Vergé L, et al · · 2024 · cited 5× · PMID 39596730 · DOI 10.3390/antibiotics13111035
Verify or expand the search:
- PubMed search for NCT02743585
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Tan Tock Seng Hospital trials
Trials by the same sponsor.
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- NCT07255859 — CRYSTALSIGHT Cohort 2.0 · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02743585 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Tan Tock Seng Hospital
- Last refreshed: 10 September 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02743585.
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