Studies of Application of Combined General Anesthesia and Bilateral Thoracic Paravertebral Block by Ropivacaine in Patients Undergoing Off-pump Coronary Artery Bridge Graft - a Random Double Blind Controlled Study

NCT02727712 Phase 4 UNKNOWN

This study intends to compare the combination of general anesthesia (GA) and single-shot bilateral thoracic paravertebral block (TPVB) by ropivacaine in the patients undergoing off-pump coronary artery bypass surgery ( OPCAB) with traditional general anesthesia (GA) perioperative management of patients, committed to reducing patient's physical and psychological stress by surgical trauma, achieve the purpose of fast recovery, in order to establish an more effective perioperative management during off-pump coronary artery bypass surgery, improve patients' satisfaction and to accelerate postoperative rehabilitation safely.

Details

Lead sponsor	Xiangya Hospital of Central South University
Phase	Phase 4
Status	UNKNOWN
Enrolment	60
Start date	2016-04
Completion	2016-12

Conditions

• Coronary Heart Disease

Interventions

• bilateral thoracic paravertebral block
• Transesophageal Echocardiography（TEE）
• Lung protection measure during the surgery（Dräger Primus）
• Anesthesia drugs during the surgery
• thoracic paravertebral block

Primary outcomes

• Fasting blood glucose — baseline and 4 days
  1day before and 4days after operation
• Blood Lactic Acid — baseline and 4 days
  1day before and 4days after operation
• Creatine kinase isoenzymes — baseline and 4 days
  1day before and 4days after operation
• Myoglobin — baseline and 4 days
  1day before and 4days after operation
• Troponin I — baseline and 4 days
  1day before and 4days after operation
• White Blood Cell — baseline and 4 days
  1day before and 4days after operation

Countries

China