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Prophylactic Racemic Epinephrine for the Prevention of Dysphagia in Patients Undergoing Anterior Cervical Discectomy and Fusion: A Randomized Control Trial
Our double-blinded, randomized control trial will assess the effect of nebulized racemic epinephrine inpatients undergoing anterior cervical discectomy and fusion (ACDF) procedures. The investigators have had success in managing post-operative dysphagia in patients undergoing ACDF with the administration of this drug. Half of the participants will review nebulized epinephrine. The other half will receive placebo.
Details
| Lead sponsor | Andrew Chung |
|---|---|
| Phase | NA |
| Status | UNKNOWN |
| Enrolment | 90 |
| Start date | 2016-09 |
| Completion | 2018-09 |
Conditions
- Dysphagia
- Dysphonia
- Postoperative Pain
Interventions
- Racemic Epinephrine
- Placebo (for racemic epinephrine)
Primary outcomes
- Change in Dysphagia Numeric Rating Scale (DNRS) — Post-operative day 1, just prior to hospital discharge (up to 1 week post-operatively), the first post-operative visit (10-14 days post-operatively, up to 30 days from surgery depending on clinical course).
It is a simple questionnaire that is a functional assessment of dysphagia i.e. difficulty swallowing solids, liquids, etc. Additionally, asks a simple "yes" and "no" question for the presence of dysphagia. - Change in Visual Analogue Scale (VAS) - Odynophagia — Post-operative day 1, just prior to hospital discharge (up to 1 week post-operatively), the first post-operative visit (10-14 days post-operatively, up to 30 days from surgery depending on clinical course).
It is a simple self-reported pain intensity scale from 0-10 with 0 being no pain, and 10 being the worst pain possible as it relates to swallowing.
Countries
United States