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NCT02718079
High-Volume Plasma Exchange Versus Standard Medical Treatment in Patients With Acute Liver Failure
NA trial testing Plasma Exchange in Acute Liver Failure in 40 participants. Completed in 18 October 2018.
8 October 2018
Quick facts
| Lead sponsor | Institute of Liver and Biliary Sciences, India |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 40 |
| Start date | 30 December 2016 |
| Primary completion | 8 October 2018 |
| Estimated completion | 18 October 2018 |
| Sites | 1 location across India |
Drugs / interventions tested
- Plasma Exchange — full drug profile →
- Management of cerebral edema/intracranial hypertension:
- Transfer to Intensive Care Unit
- Prophylactic Antibiotics — full drug profile →
- Intubation of trachea
- Administration of mannitol or 3% saline for severe elevation of Intra Cranial Pressure
- Volume Replacement — full drug profile →
- Pressor Support
- N-acetyl-L-cysteine
- Correction of metabolic parameters
- Correction of nutrition
Conditions studied
- Acute Liver Failure — all drugs for Acute Liver Failure →
Sponsor
Institute of Liver and Biliary Sciences, India
Who can join
Adults 12 to 75, any sex, with Acute Liver Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The study will be conducted on patients admitted to Department of Hepatology from Jan 2016 to Jan 2018 at Institute of Liver \& Biliary Sciences, New Delhi. Study group will comprise of patients with acute liver failure (ALF) who have no option for liver transplant (due to any reason) or have contraindications for liver transplant or have no prospective living donor and will be assessed for enrollment in the trial.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Standard-Volume Plasma Exchange Improves Outcomes in Patients With Acute Liver Failure: A Randomized Controlled Trial.
Maiwall R, Bajpai M, Singh A, Agarwal T, et al · · 2022 · cited 104× · PMID 33524593 · DOI 10.1016/j.cgh.2021.01.036
Verify or expand the search:
- PubMed search for NCT02718079
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Plasma Exchange
Trials testing the same drug.
- NCT06855667 — Efficacy and Safety of Therapeutic Plasma Exchange vs Standard Medical Therapy in Severe Autoimmune Hepatitis. · NA · not yet recruiting
- NCT06698991 — Daily Versus Alternate Day Plasma Exchange in Wilson Disease With Acute Liver Failure in Children · NA · not yet recruiting
- NCT06355726 — Efficacy of Plasma Exchange Therapy vs Standard Medical Therapy in Severe Alcoholic Hepatitis With High Discriminant Fun · NA · unknown
- NCT06276907 — An Open-label Randomized Controlled Trial Comparing the Role of Therapeutic Plasma-exchange in Ameliorating Secondary Or · NA · not yet recruiting
- NCT04871035 — Immunoadsorption Versus Plasma Exchange for Treatment of Guillain-Barré Syndrome (GBS) · recruiting
Other recruiting trials for Acute Liver Failure
Currently open trials in the same condition.
- NCT06831643 — Standard Volume vs. High Volume Plasma Exchange in Pediatric Acute Liver Failure · NA · recruiting
- NCT06872372 — Role of N-Acetylcysteine in Non-Acetaminophen-Induced Acute Liver Failure · NA · active not recruiting
- NCT07329036 — ALSS - DPMAS and Therapeutic Plasma Exchange (TPE), Its Effect on Primary Coagulation, Inflammation and the Function of · NA · recruiting
- NCT05689645 — F573 for Injection for the Treatment of Liver Injury/Failure · Phase 2 · recruiting
- NCT05413083 — Evaluation of Cardiac Function in Acutely Decompensated Cirrhosis · active not recruiting
Other Institute of Liver and Biliary Sciences, India trials
Trials by the same sponsor.
- NCT07480005 — To Revisit the Yield of Staging Laparoscopy in Hepatopancreatobiliary Malignancies · recruiting
- NCT07480057 — Assessment of Changes in Bone Mineral Metabolism After Liver Transplantation by Bone Mineral Densitometry · recruiting
- NCT07465471 — Carvedilol and Midodrine Versus Carvedilol Alone in Preventing Early Rebleed in Patients With Cirrhosis. · NA · not yet recruiting
- NCT07433881 — Serosurvey of HAV Immunity and Single-dose Vaccine Immunogenicity Among Patients With Cirrhosis · not yet recruiting
- NCT07422948 — Efficacy and Safety of Early Initiation of Midodrine for Control and Prevention of Ascites and Its Related Complications · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02718079 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Institute of Liver and Biliary Sciences, India
- Last refreshed: 20 November 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02718079.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing