Molecular Mechanisms of Antipsychotic-induced Insulin Resistance

NCT02708394 EARLY_PHASE1 COMPLETED

This study will investigate the molecular mechanisms of atypical-antipsychotic induced insulin resistance. This will be accomplished by administering olanzapine or placebo to healthy subjects for 7 days and analyzing genetic and protein changes in peripheral tissues known to play an important role in insulin resistance pathophysiology.

Details

Lead sponsor	Wayne State University
Phase	EARLY_PHASE1
Status	COMPLETED
Enrolment	31
Start date	Wed Feb 01 2017 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Sun Oct 01 2023 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Adverse Effect of Other Antipsychotics and Neuroleptics
• Insulin Resistance

Interventions

• olanzapine
• placebo

Countries

United States