Perturbing the HIV Reservoir With Immune Stimulation

NCT02707692 NA COMPLETED Results posted

The purpose of this study is to determine the impact of Pneumococcus and Influenza vaccines on the HIV transcriptional activity in individuals who are virologically suppressed for at least 48 weeks on similar ART. The proposed study is a randomized double-blinded control trial conducted over 28 weeks. Randomized interventions will be injections of Influenza vaccine, Pneumococcal vaccine, and Placebo. Each participant will receive each injection but in a randomized order.

Details

Lead sponsor	University of California, San Diego
Phase	NA
Status	COMPLETED
Enrolment	54
Start date	2016-08
Completion	2022-01

Conditions

• AIDS
• HIV

Interventions

• Fluarix
• Pneumovax
• Placebo

Primary outcomes

• Change From Vaccination (Day 0) in Mean CD4+ T Cell-associated HIV RNA Transcription at Day 7 — Day 0 and Day 7
  CD4+ T cell-associated HIV RNA was measured before vaccination on Day 0 and again on Day 7. The Day-0 measure of CD4+ T cell-associated HIV RNA transcription was subtracted from the Day-7 measure.

Countries

United States