Efficacy of Intraperitoneal Versus Intravenous Lidocaine for Postcesarean Pain Relief

NCT02707081 Phase 2/Phase 3 COMPLETED

Objective: To evaluate intraperitoneal (IP) lidocaine administration and intravenous (IV) lidocaine infusion for postoperative pain control after cesarean section. Study design: prospective randomized, double-blind, placebo-controlled study. Patients and methods: Initially, 165 pregnant full-term females, indicated to be underwent elective cesarean delivery for various indications were randomized equally to either group C (control, IP and IV saline), group IP (intraperitoneal lidocaine administration), or group IV (intravenous lidocaine infusion).Five patients were excluded from each group for various reasons. The outcome measures were postoperative pain scoring, total pethidine consumption and the need for postoperative analgesia.

Details

Lead sponsor	Benha University
Phase	Phase 2/Phase 3
Status	COMPLETED
Enrolment	150
Start date	2013-06
Completion	2015-12

Conditions

• Postcesarean Pain Relief

Interventions

• Intravenous normal saline
• Intraperitoneal normal saline
• Intraperitoneal Lidocaine
• Intravenous Lidocaine

Primary outcomes

• Postoperative pain scoring (number) — First 24 hours postoperative