NCT02696161

Platelet Rich Plasma and Perineural Injection Therapy for Carpal Tunnel Syndrome

Completed NA Last updated 19 June 2019

What this trial tests

NA trial testing platelet rich plasma in Carpal Tunnel Syndrome in 52 participants. Completed in 31 July 2017.

Timeline

1 February 2016

Primary endpoint
31 July 2017

31 July 2017

Quick facts

Lead sponsor	Tri-Service General Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	52
Start date	1 February 2016
Primary completion	31 July 2017
Estimated completion	31 July 2017
Sites	1 location across Taiwan

Drugs / interventions tested

• platelet rich plasma — full drug profile →
• 5% dextrose — full drug profile →

Conditions studied

• Carpal Tunnel Syndrome — all drugs for Carpal Tunnel Syndrome →

Sponsor

Tri-Service General Hospital

Who can join

Adults 20 to 80, any sex, with Carpal Tunnel Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy with involving compression of the median nerve in the carpal tunnel. Rather than other progressive disease, CTS is characterized by remission and recurrence. Although many conservative managements of CTS, the effectiveness of these methods is insignificant or only persist for a short duration. The platelet rich plasma (PRP) is a new and potential treatment for patients with kinds of musculoskeletal disorders and recent reports showed being beneficial for peripheral neuropathy in animal studies. Since 2014, two small clinical trials showed the positive effect of PRP in peripheral neuropathy. One study shown the PRP has therapeutic effect for peripheral neuropathy in patients with leprosy. In addition, PRP having protective effect against neurological deficit of facial nerve during superficial parotidectomy. However, these studies have not entirely proved the effects of PRP on peripheral neuropathy because these studies enrolled small number of patients and lacked controlled design. In addition, the PRP was not used for treating CTS so far. The investigators design a randomized, double-blind, controlled trail to assess the effect after ultrasound-guided PRP injection in patients with CTS.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Efficacy and safety of platelet-rich plasma in the treatment of carpal tunnel syndrome: A network meta-analysis of different injection treatments.
   Hong P, Zheng Y, Rai S, Ding Y, et al · · 2022 · cited 8× · PMID 36438824 · DOI 10.3389/fphar.2022.906075