Who is sponsoring NCT02668926?

NCT02668926 is sponsored by University Hospital, Basel, Switzerland.

What drugs are being tested in NCT02668926?

Interventions in NCT02668926: Lisdexamfetamine, d-amphetamine, Placebo, d-amphetamine, Placebo, Lisdexamfetamine, Placebo, Lisdexamfetamine, d-amphetamine.

Is NCT02668926 still recruiting?

NCT02668926 is currently completed. Last updated 10 December 2018.

Last reviewed 2018-12-10 · How we verify

NCT02668926: LisDex

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Endocrine and Emotional Effects of Lisdexamfetamine and d- Amphetamine: a Placebo-controlled Study in Healthy Subjects (LisDexStudy)

Completed Phase 1 Last updated 10 December 2018

What this trial tests

Phase 1 trial testing Lisdexamfetamine, d-amphetamine, Placebo in Healthy in 24 participants. Completed in 1 December 2016.

Timeline

1 May 2016

Primary endpoint
1 June 2016

1 December 2016

Quick facts

Lead sponsor	University Hospital, Basel, Switzerland
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	basic science
Enrollment	24
Start date	1 May 2016
Primary completion	1 June 2016
Estimated completion	1 December 2016
Sites	1 location across Switzerland

Drugs / interventions tested

Lisdexamfetamine, d-amphetamine, Placebo — full drug profile →
d-amphetamine, Placebo, Lisdexamfetamine — full drug profile →
Placebo, Lisdexamfetamine, d-amphetamine — full drug profile →

Conditions studied

Healthy — all drugs for Healthy →

Sponsor

University Hospital, Basel, Switzerland

Who can join

Adults 18 to 45, any sex, with Healthy. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Effects of lisdexamphetamine and d-Amphetamine on circulating steroidal hormones
Time frame: 13 hours
Measurement of different circulating hormones before and after drug
Subjective effects of lisdexamphetamine and d-amphetamine
Time frame: 13 hours
Assessment of subjective effects using visual analog scales

Sponsor's own description

The study will compare the acute emotional and endocrine effects of equivalent doses of lisdexamfetamine and amphetamine in healthy subjects. In addition the pharmacokinetics and effects of the amphetamines on aspects of social cognition are investigated.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Pharmacokinetics and Pharmacodynamics of Lisdexamfetamine Compared with D-Amphetamine in Healthy Subjects.
Dolder PC, Strajhar P, Vizeli P, Hammann F, et al · · 2017 · cited 37× · PMID 28936175 · DOI 10.3389/fphar.2017.00617
Acute effects of lisdexamfetamine and D-amphetamine on social cognition and cognitive performance in a placebo-controlled study in healthy subjects.
Dolder PC, Strajhar P, Vizeli P, Odermatt A, et al · · 2018 · cited 28× · PMID 29511807 · DOI 10.1007/s00213-018-4849-0

Verify or expand the search:

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Other University Hospital, Basel, Switzerland trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02668926 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Basel, Switzerland
Last refreshed: 10 December 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02668926.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing