NCT02665377 is a Phase 3 clinical trial of ANP in Acute Kidney Injury, sponsored by Sahlgrenska University Hospital.

Who is sponsoring NCT02665377?

NCT02665377 is sponsored by Sahlgrenska University Hospital.

What drugs are being tested in NCT02665377?

Interventions in NCT02665377: ANP, Placebo.

What condition does NCT02665377 study?

NCT02665377 studies Acute Kidney Injury.

Is NCT02665377 still recruiting?

NCT02665377 is currently completed. Last updated 9 February 2022.

Last reviewed 2022-02-09 · How we verify

NCT02665377

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Prevention of Akute Kidney Injury, Hearttransplant, ANP

Completed Phase 3 Last updated 9 February 2022

What this trial tests

Phase 3 trial testing ANP in Acute Kidney Injury in 86 participants. Completed in 8 January 2022.

Timeline

25 September 2016

Primary endpoint
8 January 2022

8 January 2022

Quick facts

Lead sponsor	Sahlgrenska University Hospital
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	prevention
Enrollment	86
Start date	25 September 2016
Primary completion	8 January 2022
Estimated completion	8 January 2022
Sites	1 location across Sweden

Drugs / interventions tested

ANP — full drug profile →
Placebo

Conditions studied

Acute Kidney Injury — all drugs for Acute Kidney Injury →

Sponsor

Sahlgrenska University Hospital

Who can join

18 and older, any sex, with Acute Kidney Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Prospective, blinded, placebo-controlled trial. Patients: Adult patients (\>18 years of age) undergoing de novo Htx, with a preoperative GFR \> 30ml/min, not receiving an ABO-incompatible organ with an ischemia time of \> 6 hours. A donor age \> 70 years is an exclusion criteria. Intervention: Infusion of h-ANP fore five days, starting at the induction of anesthesia. Outcome: Kidney function, evaluated with serum creatinine day 1-7 and kidney clearance, 4-5 Days after Htx plus after 3 and 12 months.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Perioperative Acute Kidney Injury.
Gumbert SD, Kork F, Jackson ML, Vanga N, et al · · 2020 · cited 209× · PMID 31687986 · DOI 10.1097/aln.0000000000002968
Novel therapeutics for the treatment of hypertension and its associated complications: peptide- and nonpeptide-based strategies.
Ghatage T, Goyal SG, Dhar A, Bhat A. · · 2021 · cited 54× · PMID 33731923 · DOI 10.1038/s41440-021-00643-z

Verify or expand the search:

Other recruiting trials for Acute Kidney Injury

Currently open trials in the same condition.

NCT07273838 — Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome · Phase 2 · recruiting
NCT07262320 — Epidemiology and Processes of Care for Renal Replacement Therapy in Acute Kidney Injury in Latin America · recruiting
NCT07351149 — Postoperative Acute Kidney Injury in Children Undergoing Major Non-cardiac Surgery · recruiting
NCT07215702 — A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kid · Phase 2 · recruiting
NCT06654193 — Allogeneic HB-adMSCs vs Placebo for the Treatment of Acute Kidney Injury · Phase 1, PHASE2 · recruiting

Other Sahlgrenska University Hospital trials

Trials by the same sponsor.

NCT07491094 — Repeated Examinations for Typing Pulmonary Embolism · recruiting
NCT07524608 — Implementing an Evidence-based, Standardized Care Bundle Targeting Register Nurses and Anaesthesiologists, to Enhance Pa · not yet recruiting
NCT07498959 — Primary RPLND Versus Systemic Chemotherapy in Good-prognosis Metastatic Testicular Cancer · NA · recruiting
NCT06896578 — Latitude - Lateral Lymph Node Attitude Study · NA · not yet recruiting
NCT07035600 — Walking and Sitting Difficulties After Rectal Cancer Surgery · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02665377 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Sahlgrenska University Hospital
Last refreshed: 9 February 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02665377.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing