Preventing Metabolic Side Effects of Thiazide Diuretics With KMgCitrate

NCT02665117 NA COMPLETED Results posted

Chlorthalidone (CTD) may produce various metabolic disturbances, including hypokalemia, activation of Renin-Angiotensin- Aldosterone (RAA) system, oxidative stress, dyslipidemia, Fibroblast growth factor 23 (FGF23) synthesis, and magnesium depletion. These factors may interact with each other to contribute to the development of insulin resistances and metabolic syndrome. Smaller studies have suggested that Potassium magnesium Citrate (KMgCit) can ameliorate CTD- induced metabolic side effects independent of correction of hypokalemia. This study will tests if KMgCit ameliorates CTD induced metabolic effects independent of correction of hypokalemia.

Details

Lead sponsor	University of Texas Southwestern Medical Center
Phase	NA
Status	COMPLETED
Enrolment	61
Start date	2015-01
Completion	2022-11-04

Conditions

• Hypertension

Interventions

• Potassium Magnesium Citrate (KMgCit)
• Potassium Chloride (KCl)
• Chlorthalidone

Primary outcomes

• Change in Fasting Plasma Glucose From Week 4 to Week 16 — week 4 and week 16
  Fasting plasma glucose was measured from venous blood sample at week 4 and week 16

Countries

United States