Rapid Diagnostic Testing to Guide Antibiotic Therapy in Drug Resistant Pneumonia

NCT02660554 NA COMPLETED

The purpose of this study is to conduct a randomized clinical trial to compare an antibiotic strategy based on a novel diagnostic test, polymerase chain reaction (PCR) to usual care, in critically ill adults with pneumonia suspected to be caused by methicillin resistant staphylococcus aureus (MRSA). The investigators hypothesize that when automated PCR is used to guide antibiotic therapy, antibiotic exposure will be reduced in critically ill subjects with pneumonia.

Details

Lead sponsor	Northwestern University
Phase	NA
Status	COMPLETED
Enrolment	45
Start date	2016-01
Completion	2019-05-03

Conditions

• Pneumonia
• Methicillin-Resistant Staphylococcus Aureus

Interventions

• Polymerase Chain Reaction (PCR)

Primary outcomes

• Days of anti-MRSA antibiotic therapy — 14 days
  days for initially suspected MRSA pneumonia

Countries

United States