Community-led Responses for Elimination (CoRE): A Cluster Randomized Controlled Trial of Reactive Case Detection Versus Reactive Drug Administration in Malaria Elimination Areas in Southern Province Zambia (CORE Zambia)

NCT02654912 Phase 4 COMPLETED

This study is designed to compare the effectiveness of reactive focal drug administration (RFDA) using dihydroartemisinin+piperaquine (DHAP) versus reactive focal test and treat (RFTAT) using artemether+lumefantrine (AL) as a routine process for identifying and eliminating malaria transmission as measured through achieving zero seropositivity in children under five in Southern Province, Zambia. These two strategies are potential candidates for expanded malaria operational surveillance and elimination for low malaria transmission areas.

Details

Lead sponsor	PATH
Phase	Phase 4
Status	COMPLETED
Enrolment	8682
Start date	2016-02
Completion	2020-07

Conditions

• Malaria

Interventions

• Reactive Focal Drug Administration

Primary outcomes

• Malaria seropositivity in children under five — 24 months
  Malaria seropositivity in children under five after two-year intervention within health center catchment areas

Countries

Zambia