Last reviewed · How we verify
Effect of Heavy Alcohol Consumption on Farnesoid X Receptor (FXR) Signaling
The main purpose of this study is to see whether heavy drinking will interfere with a specific pathway, called FXR signaling in the liver. The abnormality of this pathway may lead to liver injury in some patients who drink heavily.
Details
| Lead sponsor | Suthat Liangpunsakul |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 30 |
| Start date | 2016-04 |
| Completion | 2019-09 |
Conditions
- Alcohol Consumption
Interventions
- Placebo
- 10 mg Obeticholic Acid (OCA)
Primary outcomes
- Change in Bile Salt Metabolism (C4 )Levels to Determine Effect of FXR — Baseline to 28 days
- Change in FGF19 Levels to Determine Effect of FXR — Baseline to 28 days
Countries
United States