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A Lifestyle Intervention to Improve in Vitro Fertilization Results (W+D)
Embryo adhesion and placentation depend on tissue plasminogen activator (tPA)-mediated activation of brain-derived neurotrophic factor, vascular endothelial growth factor and other growth factors, formation of hemidesmosomes, and degradation of extracellular matrix and basement membrane, either directly or by activating matrix metalloproteinases. Since glucose and insulin stimulate release of a major tPA inhibitor by endothelial cells - plasminogen activator inhibitor (PAI)-1 - the investigators hypothesized that lifestyle interventions proven effective in maintaining glucose and insulin levels within the normal range would increase the take home baby rate in women undergoing assisted reproduction.
Details
| Lead sponsor | Hospital dos Servidores do Estado do Rio de Janeiro |
|---|---|
| Phase | NA |
| Status | UNKNOWN |
| Enrolment | 240 |
| Start date | 2016-05 |
| Completion | 2018-05 |
Conditions
- Sterility
- Placenta; Implantation
- Risk Reduction Behavior
- Lifestyle
- Neonatal Hypoglycemia
Interventions
- Daily walking
- Dietary recommendations
Primary outcomes
- The rate of viable pregnancies — two years
Countries
Brazil