NCT02622204 (Osteotomy) is a clinical trial of Corrective osteotomy in Knee Osteoarthritis, sponsored by University Hospital, Basel, Switzerland.

Who is sponsoring NCT02622204?

NCT02622204 is sponsored by University Hospital, Basel, Switzerland.

What drugs are being tested in NCT02622204?

Interventions in NCT02622204: Corrective osteotomy.

What condition does NCT02622204 study?

NCT02622204 studies Knee Osteoarthritis.

Is NCT02622204 still recruiting?

NCT02622204 is currently completed. Last updated 6 October 2021.

Last reviewed 2021-10-06 · How we verify

NCT02622204: Osteotomy

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effect of Corrective Osteotomy on in Vivo Cartilage Mechanobiology in Patients With Knee Osteoarthritis

Completed Last updated 6 October 2021

What this trial tests

trial testing Corrective osteotomy in Knee Osteoarthritis in 24 participants. Completed in 31 December 2020.

Timeline

1 January 2016

Primary endpoint
31 August 2020

31 December 2020

Quick facts

Lead sponsor	University Hospital, Basel, Switzerland
Status	Completed
Study type	OBSERVATIONAL
Enrollment	24
Start date	1 January 2016
Primary completion	31 August 2020
Estimated completion	31 December 2020
Sites	1 location across Switzerland

Drugs / interventions tested

Corrective osteotomy

Conditions studied

Knee Osteoarthritis — all drugs for Knee Osteoarthritis →

Sponsor

University Hospital, Basel, Switzerland

Who can join

Adults 18 to 70, any sex, with Knee Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Our overall hypothesis is that a sudden ambulatory load reduction (caused by corrective osteotomy) leads to changes in cartilage biology that delay or reverse osteoarthritic processes determining the clinical outcome and representing an in vivo model for assessing cartilage mechanosensitivity.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

High tibial osteotomy effectively redistributes compressive knee loads during walking.
De Pieri E, Nüesch C, Pagenstert G, Viehweger E, et al · · 2023 · cited 28× · PMID 35730475 · DOI 10.1002/jor.25403
Assessing in vivo articular cartilage mechanosensitivity as outcome of high tibial osteotomy in patients with medial compartment osteoarthritis: Experimental protocol.
Mündermann A, Vach W, Pagenster G, Egloff C, et al · · 2020 · cited 5× · PMID 36474590 · DOI 10.1016/j.ocarto.2020.100043
Load-induced blood marker kinetics in patients with medial knee compartment osteoarthritis are associated with accumulated load and patient reported outcome measures.
Mündermann A, Nüesch C, Herger S, Liphardt AM, et al · · 2023 · cited 4× · PMID 38882712 · DOI 10.12688/f1000research.131702.2
Load-induced blood marker kinetics in patients with medial knee compartment osteoarthritis are associated with accumulated load and patient reported outcome measures
Mündermann A, Nüesch C, Herger S, Liphardt A, et al · · 2024 · DOI 10.12688/f1000research.131702.2

Verify or expand the search:

Other trials of Corrective osteotomy

Trials testing the same drug.

NCT05700526 — Customized Bone Allografts by 3D-printing · NA · enrolling by invitation
NCT05051709 — Can Hypermobility of First Ray Affect Surgical Treatment of Hallux Valgus · NA · unknown

Other recruiting trials for Knee Osteoarthritis

Currently open trials in the same condition.

NCT06906939 — A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression · EARLY_PHASE1 · recruiting
NCT05823727 — Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing Afte · NA · recruiting
NCT07370480 — Knee Osteoarthritis and Thermal Spa Treatment · NA · recruiting
NCT07507175 — Gastrocnemius Myofascial Release in Females With Knee Osteoarthritis · NA · recruiting
NCT07386600 — Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA · NA · recruiting

Other University Hospital, Basel, Switzerland trials

Trials by the same sponsor.

NCT07444788 — Acute Effects of Intravenous 5-MeO-DMT in Healthy Participants · Phase 1 · recruiting
NCT07494214 — Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia in Healthy Participants · Phase 1 · recruiting
NCT07419048 — Artificial Intelligence or Human Hand? Evaluating Inferior Vena Cava Imaging for Hydration Status · recruiting
NCT06978777 — Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity · NA · recruiting
NCT07273630 — Effect of Protein Supplementation and Fluid Restriction on Plasma Sodium Levels in Patients Undergoing Pituitary Surgery · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02622204 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Basel, Switzerland
Last refreshed: 6 October 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02622204.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing