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Omega-3 Fatty Acid Supplementation and Resistance Training on Inflammation and Body Composition in Older Men
The purpose of this project is to evaluate whether omega-3 fatty acid supplementation (combined eicosapentaenoic acid and docosahexaenoic acid \[EPA/DHA\] supplement) augments the effects of a 12-week resistance training program in older men. Outcome variables include inflammatory biomarkers in the systemic circulation, body composition and performance measures. The specific inflammatory markers in the blood include: C-reactive protein, tumor necrosis factor-α, interleukin-1β, and interleukin-6. Remaining parameters include: body composition (as assessed by dual energy x-ray absorptiometry), muscle strength (as assessed by chest press and leg press one-repetition maximum strength tests), and functional ability (as assessed by timed up and go test as well as the 6-minute walking test).
Details
| Lead sponsor | University of Manitoba |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 24 |
| Start date | 2015-10 |
| Completion | 2016-11 |
Conditions
- Sarcopenia
- Dynapenia
- Inflammation
Interventions
- Omega-3 Supplementation
- Placebo
Primary outcomes
- Tumor Necrosis Factor-alpha — 12 weeks
The cytokine tumor necrosis factor-alpha will be used as the primary outcome to assess change in inflammatory status over the 12 week intervention
Countries
Canada