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NCT02604667: MOST-CA
Mechanisms of Ischemic Stroke in Cancer Patients
trial testing Blood tests in Stroke in 150 participants. Completed in 1 September 2020.
1 September 2020
Quick facts
| Lead sponsor | Weill Medical College of Cornell University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 150 |
| Start date | 8 April 2016 |
| Primary completion | 1 September 2020 |
| Estimated completion | 1 September 2020 |
| Sites | 2 locations across United States |
Drugs / interventions tested
- Blood tests — full drug profile →
- Transcranial Doppler Microemboli Detection Study
Conditions studied
Sponsor
Weill Medical College of Cornell University
Who can join
18 and older, any sex, with Stroke or Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to better understand the causes of stroke in people with cancer. Active cancer increases the risk of stroke. The investigators do not know exactly why this occurs but one possible reason is that people with cancer may have thicker blood than people without cancer. Thick blood can sometimes cause blood clots to form in the heart, which can then travel to the brain and cause stroke. This study is being done to help figure out why this and other causes of stroke occur in people with cancer. The investigators expect that information from this study will help doctors to more effectively prevent and treat stroke in individuals with cancer.
Publications & conference data
5 peer-reviewed publications reference this trial (live from Europe PMC):
-
Ischemic stroke in cancer patients: A review of an underappreciated pathology.
Navi BB, Iadecola C. · · 2018 · cited 206× · PMID 29633334 · DOI 10.1002/ana.25227 -
Cancer and Embolic Stroke of Undetermined Source.
Navi BB, Kasner SE, Elkind MSV, Cushman M, et al · · 2021 · cited 122× · PMID 33504187 · DOI 10.1161/strokeaha.120.032002 -
Mechanisms of Ischemic Stroke in Patients with Cancer: A Prospective Study.
Navi BB, Sherman CP, Genova R, Mathias R, et al · · 2021 · cited 58× · PMID 34029423 · DOI 10.1002/ana.26129 -
Ischemic stroke with cancer: Hematologic and embolic biomarkers and clinical outcomes.
Navi BB, Zhang C, Sherman CP, Genova R, et al · · 2022 · cited 24× · PMID 35652416 · DOI 10.1111/jth.15779 -
Cancer-Related Ischemic Stroke Has a Distinct Blood mRNA Expression Profile.
Navi BB, Mathias R, Sherman CP, Wolfe J, et al · · 2019 · cited 18× · PMID 31510897 · DOI 10.1161/strokeaha.119.026143
Verify or expand the search:
- PubMed search for NCT02604667
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Stroke
Currently open trials in the same condition.
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Other Weill Medical College of Cornell University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02604667 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Weill Medical College of Cornell University
- Last refreshed: 5 May 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02604667.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing