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NCT02604667: MOST-CA

Mechanisms of Ischemic Stroke in Cancer Patients

Completed Last updated 5 May 2021
What this trial tests

trial testing Blood tests in Stroke in 150 participants. Completed in 1 September 2020.

Timeline
8 April 2016
Primary endpoint
1 September 2020
1 September 2020

Quick facts

Lead sponsorWeill Medical College of Cornell University
StatusCompleted
Study typeOBSERVATIONAL
Enrollment150
Start date8 April 2016
Primary completion1 September 2020
Estimated completion1 September 2020
Sites2 locations across United States

Drugs / interventions tested

Conditions studied

Sponsor

Weill Medical College of Cornell University

Who can join

18 and older, any sex, with Stroke or Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to better understand the causes of stroke in people with cancer. Active cancer increases the risk of stroke. The investigators do not know exactly why this occurs but one possible reason is that people with cancer may have thicker blood than people without cancer. Thick blood can sometimes cause blood clots to form in the heart, which can then travel to the brain and cause stroke. This study is being done to help figure out why this and other causes of stroke occur in people with cancer. The investigators expect that information from this study will help doctors to more effectively prevent and treat stroke in individuals with cancer.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Ischemic stroke in cancer patients: A review of an underappreciated pathology.
    Navi BB, Iadecola C. · · 2018 · cited 206× · PMID 29633334 · DOI 10.1002/ana.25227
  2. Cancer and Embolic Stroke of Undetermined Source.
    Navi BB, Kasner SE, Elkind MSV, Cushman M, et al · · 2021 · cited 122× · PMID 33504187 · DOI 10.1161/strokeaha.120.032002
  3. Mechanisms of Ischemic Stroke in Patients with Cancer: A Prospective Study.
    Navi BB, Sherman CP, Genova R, Mathias R, et al · · 2021 · cited 58× · PMID 34029423 · DOI 10.1002/ana.26129
  4. Ischemic stroke with cancer: Hematologic and embolic biomarkers and clinical outcomes.
    Navi BB, Zhang C, Sherman CP, Genova R, et al · · 2022 · cited 24× · PMID 35652416 · DOI 10.1111/jth.15779
  5. Cancer-Related Ischemic Stroke Has a Distinct Blood mRNA Expression Profile.
    Navi BB, Mathias R, Sherman CP, Wolfe J, et al · · 2019 · cited 18× · PMID 31510897 · DOI 10.1161/strokeaha.119.026143

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Other trials of Blood tests

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Other recruiting trials for Stroke

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Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02604667.

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