Last reviewed · How we verify
Effects of Intranasal Oxytocin on Cigarette Smoking
Socioemotional processing dysfunctions (i.e., disruptions in affective, cognitive, and neural processes that encode, interpret, and respond to socially and emotionally relevant stimuli) have been implicated in tobacco smoking and relapse, however this potential target for medication development has not been systematically examined. Evidence from animal and human laboratories indicate that administration of intranasal oxytocin enhances socioemotional processing and may be efficacious for the treatment of drug addiction, including nicotine dependence. In order to evaluate the potential efficacy of intranasal oxytocin for smoking cessation, this laboratory-based proposal will examine whether intranasal oxytocin attenuates smoking lapse, nicotine withdrawal, and socioemotional processing disruptions in regular smokers following overnight abstinence.
Details
| Lead sponsor | University of Southern California |
|---|---|
| Phase | Phase 4 |
| Status | COMPLETED |
| Enrolment | 83 |
| Start date | 2016-07 |
| Completion | 2019-07 |
Conditions
- Nicotine Dependence
- Tobacco Smoking
Interventions
- Oxytocin
- Placebo
Primary outcomes
- Smoking Lapse Analogue Task (Delay Score) — 2.5 hours after nasal spray administration
This task measures ability to resist the temptation to initiate smoking under conditions in which it is advantageous to remain abstinent. The "delay score" is the number of minutes before participants begin smoking (minimum = 0 minutes to maximum = 50 minutes). A higher number is better. - Brief Questionnaire of Smoking Urges (QSU) — 30 minutes before nasal spray, and 30, 60, and 90 minutes after nasal spray
The Brief Questionnaire of Smoking Urges (QSU) is a 10-item self-report questionnaire measures desire, intention, urge, and need to smoke. The QSU was assessed 30 minutes before the nasal spray, and again 30, 60, and 90 minutes after the nasal spray during each session. Scores at each assessment time are calculated as the mean of all 10 items (minimum = 0 to maximum = 5). Each session's scores are then calculated as the mean scores of post-spray assessments. A lower score is better. - Systolic Blood Pressure (mmHg) — 30 minutes before nasal spray, and 30, 60, and 90 minutes after nasal spray
Systolic blood pressure (SP) was assessed 30 minutes before the nasal spray, and again 30, 60, and 90 minutes after the nasal spray during each session. Each session's values are calculated as the mean of post-spray assessments. - Diastolic Blood Pressure (mmHg) — 30 minutes before nasal spray, and 30, 60, and 90 minutes after nasal spray
Diastolic blood pressure (DP) was assessed 30 minutes before the nasal spray, and again 30, 60, and 90 minutes after the nasal spray during each session. Each session's values are calculated as the mean of post-spray assessments. - Heart Rate (Bpm) — 30 minutes before nasal spray, and 30, 60, and 90 minutes after nasal spray
Heart rate (HR) was assessed 30 minutes before the nasal spray, and again 30, 60, and 90 minutes after the nasal spray during each session. Each session's values are calculated as the mean of post-spray assessments.
Countries
United States