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Treatment of Hypertension In Adults With ThiaZIDES: Pragmatic Trial Pilot Study
This proposed pilot study will test methods and feasibility for a large pragmatic clinical trial comparing two inexpensive, first-line drugs for treating high blood pressure to determine if one is superior in preventing serious cardiovascular events and death. It will develop and test novel approaches to conducting trials that will be faster, less expensive, and more realistic by being embedded in a typical practice setting and using advanced health information technology.
Details
| Lead sponsor | HealthPartners Institute |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 2027 |
| Start date | 2015-08 |
| Completion | 2017-07 |
Conditions
- Hypertension
Interventions
- HCTZ prescription conversion to chlorthalidone
Primary outcomes
- Conversion to chlorthalidone, number of patients with primary fills — 3 months
We will observe pharmacy claims to assess whether intervention patients filled their first prescription for chlorthalidone (primary adherence) - Conversion to chlorthalidone, number of participants with secondary fills — 9 months
We will observe pharmacy claims to assess whether intervention patients who filled their first chlorthalidone prescription also filled their subsequent prescription (secondary adherence)
Countries
United States