NCT02586532

Evaluation of the Sensitivity of Endoscopy to Detect Nasopharyngeal Carcinoma (NPC) in an Epstein-Barr Virus (EBV)-Based NPC Screening Project in China

Completed Last updated 11 December 2020

What this trial tests

trial in Nasopharyngeal Cancinoma (NPC) in 828 participants. Completed in 5 June 2020.

Timeline

19 October 2015

Primary endpoint
5 June 2020

5 June 2020

Quick facts

Lead sponsor	National Cancer Institute (NCI)
Status	Completed
Study type	OBSERVATIONAL
Enrollment	828
Start date	19 October 2015
Primary completion	5 June 2020
Estimated completion	5 June 2020
Sites	1 location across China

Conditions studied

• Nasopharyngeal Cancinoma (NPC) — all drugs for Nasopharyngeal Cancinoma (NPC) →

Sponsor

National Cancer Institute (NCI)

Who can join

Adults 30 to 59, any sex, with Nasopharyngeal Cancinoma (NPC). Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background:

Epstein-Barr virus (EBV) can cause the cancer nasopharyngeal carcinoma (NPC). Early detection of NPC through screening can lead to better treatment outcomes than when it is found later. Currently, NPC is found through visual inspection with an endoscope. It is not clear how well this method works, especially for the identification of small, early cancers. Researchers want to see how well nasal endoscopy works to detect NPC compared to another method called magnetic resonance imaging (MRI).

Objectives:

To evaluate the sensitivity of endoscopy to detect prevalent NPC among people who screen positive for EBV antibodies.

Eligibility:

Participants of the NPC Early Detection Screening Program in China who:

Have increased levels of EBV antibodies

Are otherwise in good health and able to have an MRI procedure

Design:

Participants will be screened with a blood test.

Participants will have a nasal endoscopy.

Participants will have an MRI of the head and neck:

Participants will have lesions identified by either the endoscopy or MRI biopsied and sent to a pathologist for review and diagnosis of NPC.

Researchers will compare NPC detection rates by endoscopy and by MRI to see which method is better able to identify prevalent NPC.

...

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Development and validation of a flexible DNA extraction (PAN) method for liquid biopsy of multiple sample types.
   Chen XX, Chen W, Liu YL, Lin CX, et al · · 2021 · cited 1× · PMID 34399000 · DOI 10.1002/jcla.23962