NCT02573922 (oksineukir) is a Phase 4 clinical trial of oxycodone-naloxone in Constipation, sponsored by Kuopio University Hospital.

Who is sponsoring NCT02573922?

NCT02573922 is sponsored by Kuopio University Hospital.

What drugs are being tested in NCT02573922?

Interventions in NCT02573922: oxycodone-naloxone, Oxycodone.

What condition does NCT02573922 study?

NCT02573922 studies Constipation.

Is NCT02573922 still recruiting?

NCT02573922 is currently completed. Last updated 9 October 2015.

Last reviewed 2015-10-09 · How we verify

NCT02573922: oksineukir

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Opioid Induced Bowel Dysfunction in Patients Undergoing Spinal Surgery

Completed Phase 4 Last updated 9 October 2015

What this trial tests

Phase 4 trial testing oxycodone-naloxone in Constipation in 180 participants. Completed in 1 December 2014.

Timeline

1 May 2012

Primary endpoint
1 December 2014

1 December 2014

Quick facts

Lead sponsor	Kuopio University Hospital
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	180
Start date	1 May 2012
Primary completion	1 December 2014
Estimated completion	1 December 2014
Sites	1 location across Finland

Drugs / interventions tested

oxycodone-naloxone — full drug profile →
Oxycodone (oxycodone) — full drug profile →

Conditions studied

Constipation — all drugs for Constipation →

Sponsor

Kuopio University Hospital

Who can join

Adults 18 to 75, any sex, with Constipation. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

opioid induced constipation
Time frame: from the surgery up to 21 days
Opioid induced constipation was assessed with bowel function index

Sponsor's own description

In the present study, the primary aim was to evaluate if oxycodone-naloxone combination compared to oxycodone reduced opioid induced constipation in patients with or without chronic opioid treatment undergoing spine surgery.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Opioid-Induced Bowel Dysfunction in Patients Undergoing Spine Surgery: Comparison of Oxycodone and Oxycodone-Naloxone Treatment.
Kokki M, Kuronen M, Naaranlahti T, Nyyssönen T, et al · · 2017 · cited 12× · PMID 27921252 · DOI 10.1007/s12325-016-0456-9

Verify or expand the search:

Other recruiting trials for Constipation

Currently open trials in the same condition.

NCT07462481 — Probiotic Improve Constipation · NA · recruiting
NCT07466914 — Constipation in Children With Cerebral Palsy · active not recruiting
NCT07215351 — Impact of the Inno Cleanse Dietary Supplement on Gut Health and Associated Variables in Healthy Men and Women · NA · recruiting
NCT07135362 — The Efficacy Evaluation of TCI604 Probiotic on Intestinal Function Improvement · NA · recruiting
NCT07091084 — A Study of Herbal Supplements in Cancer Survivors With Constipation · NA · recruiting

Other Kuopio University Hospital trials

Trials by the same sponsor.

NCT06725433 — Nissen Versus Dor Hiatal Hernia Repair · NA · recruiting
NCT06495268 — Healthy heaAring for Healthy Ageing: Data-driven Hearing Rehabilitation Intervention to Promote Healthy Hearing · NA · active not recruiting
NCT06740097 — Feasibility of Aspirate Tissue Monitoring in Neuro-oncological Surgery · NA · recruiting
NCT06460363 — Transcranial Alternating Current Stimulation on Patients with Delirium and Critical Illness (DeliTACS) · NA · recruiting
NCT05863624 — Open and Endoscopic Technique in Female Inguinal Hernia Repair. FemaleHernia · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02573922 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Kuopio University Hospital
Last refreshed: 9 October 2015

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02573922.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing