Comparison of Two Methods of Transfusion for Stroke Prevention in Sickle Cell

NCT02561312 COMPLETED

Chronic blood transfusions are essential supportive care for sickle cell patients at high risk for morbidity and mortality due to stroke. These patients, however, are at risk for iron overload. In the investigator's comprehensive sickle cell center, the investigators support chronic transfusion with rapid manual partial exchange transfusions (RMPET) using a single access central line port. The investigators do not have a comprehensive adult sickle cell program but upon transition of patients the patients would be provided simple transfusion (ST) in an adult ambulatory infusion setting due to nursing acuity needed for RMPET. The investigators plan to study the institution's participants currently on chronic transfusion support and compare different transfusion modalities to better understand the effects from switching from RMPET to ST. To date, there are no such comparisons within and between sickle cell patients in the literature.

Details

Lead sponsor	Chattanooga-Hamilton County Hospital Authority
Status	COMPLETED
Enrolment	9
Start date	2015-09
Completion	2017-09-30

Conditions

• Anemia, Sickle Cell
• Sickling Disorder Due to Hemoglobin S

Interventions

• Rapid manual partial exchange transfusion
• Simple Transfusion

Primary outcomes

• Hemoglobin S, baseline hemoglobin/hematocrit, — Pre Infusion, lab collected monthly for one year thru study completion
  Lab parameters pre-infusion for each method of transfusion

Countries

United States