NCT02537314 is a Phase 1 clinical trial of benzocaine in Obesity, sponsored by Vanderbilt University Medical Center.

Who is sponsoring NCT02537314?

NCT02537314 is sponsored by Vanderbilt University Medical Center.

What drugs are being tested in NCT02537314?

Interventions in NCT02537314: benzocaine, placebo.

Is NCT02537314 still recruiting?

NCT02537314 is currently completed. Last updated 8 December 2022.

Last reviewed 2022-12-08 · How we verify

NCT02537314

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Role of the Foregut in Nutrient Metabolism in Lean and Obese Humans

Completed Phase 1 Last updated 8 December 2022

What this trial tests

Phase 1 trial testing benzocaine in Obesity in 27 participants. Completed in 8 December 2022.

Timeline

1 September 2015

Primary endpoint
8 December 2022

8 December 2022

Quick facts

Lead sponsor	Vanderbilt University Medical Center
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	basic science
Enrollment	27
Start date	1 September 2015
Primary completion	8 December 2022
Estimated completion	8 December 2022
Sites	1 location across United States

Drugs / interventions tested

benzocaine (BENZOCAINE) — full drug profile →
placebo

Conditions studied

Obesity — all drugs for Obesity →

Sponsor

Vanderbilt University Medical Center

Who can join

Adults 20 to 50, any sex, with Obesity. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Gastrointestinal Hormones
Time frame: 5 Hours
Plasma levels of Cholecystokinin, gastric inhibitory peptide and glucagon like peptide and Ghrelin
Pancreatic Hormones
Time frame: 5 Hours
Plasma levels of Insulin, C-peptide, Glucagon
Glucose and Free Fatty Acids
Time frame: 5 Hours
Plasma levels

Sponsor's own description

The overall hypothesis of this proposal is that nutrient sensing in the foregut regulates metabolic hormone secretion and nutrient metabolism via enteric neural signals, and these mechanisms might be defective in obesity.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Intraduodenal nutrient infusion differentially alters intestinal nutrient sensing, appetite, and satiety responses in lean and obese subjects.
Sundaresan S, Johnson C, Dixon KB, Dole M, et al · · 2023 · cited 10× · PMID 37661107 · DOI 10.1016/j.ajcnut.2023.06.011

Verify or expand the search:

Other recruiting trials for Obesity

Currently open trials in the same condition.

NCT07403604 — Effect of Insulin Lowering on Lipogenesis · Phase 1 · recruiting
NCT07509307 — AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee · Phase 3 · recruiting
NCT07272837 — Impact of Semaglutide (Ozempic/Wegovy®) on Heart and Muscle Mass · recruiting
NCT07481630 — A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoart · Phase 3 · recruiting
NCT07527195 — Understanding the Effect of CagriSema, Cagrilintide, and Semaglutide on Muscle Health (Role of Amylin Signature in Muscl · Phase 1 · recruiting

Other Vanderbilt University Medical Center trials

Trials by the same sponsor.

NCT07005037 — Swallowing Impairments in ICU Survivors and Community-Dwelling Adults · not yet recruiting
NCT07527273 — Cognitive Enhancement in Recurrent Depression (The COG-D-R Study) · NA · not yet recruiting
NCT07295288 — Botox Injections in Non-Cranial Nerve VII Innervated Muscles for Facial Synkinesis · Phase 4 · not yet recruiting
NCT07431541 — Topical Carboxytherapy Paste Following Microneedling · Phase 1, PHASE2 · not yet recruiting
NCT07224711 — The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery · Phase 4 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02537314 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Vanderbilt University Medical Center
Last refreshed: 8 December 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02537314.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing