Skeletal Muscle Dysfunction in Rheumatoid Arthritis (RA)

NCT02535832 Phase 1 COMPLETED

Muscle strength helps determine a person's quality of life and functional independence. Patients with rheumatoid arthritis often suffer from muscle weakness and a pre-diabetic condition called insulin resistance. By doing this study, the investigators hope to learn why patients with rheumatoid arthritis (RA) suffer from muscle weakness.

Details

Lead sponsor	Ohio State University
Phase	Phase 1
Status	COMPLETED
Enrolment	16
Start date	2015-09
Completion	2022-10

Conditions

• Rheumatoid Arthritis
• Insulin Resistance

Interventions

• Pioglitazone
• Placebo

Primary outcomes

• Insulin sensitivity — Baseline
  2 hour oral glucose tolerance test will be performed after a 12-hour fast using 75 g glucose
• Skeletal muscle strength in the quadriceps muscle — Changes from baseline and 12 weeks
  isometric strength test of the lower-extremity muscles (with one leg extension) using a Biodex to measure maximum voluntary isometric contraction (MVIC)
• Monocytosis in peripheral blood — Changes from baseline and 12 weeks
  White blood cell populations will be isolated using flow cytometry.

Countries

United States