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NCT02529189: NITRATE-OCT
Investigating the Effects of Dietary Nitrate on Vascular Function, Platelet Reactivity and Restenosis in Stable Angina
Phase 2 trial testing Beetroot Juice in Cardiovascular Diseases in 300 participants. Completed in 31 December 2022.
31 December 2022
Quick facts
| Lead sponsor | Queen Mary University of London |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 300 |
| Start date | 2 November 2015 |
| Primary completion | 31 December 2022 |
| Estimated completion | 31 December 2022 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Beetroot Juice — full drug profile →
- Beetroot Juice — full drug profile →
Conditions studied
- Cardiovascular Diseases — all drugs for Cardiovascular Diseases →
Sponsor
Queen Mary University of London
Who can join
Adults 18 to 85, any sex, with Cardiovascular Diseases. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The mainstay treatment for reducing the symptoms of angina and long-term risk of heart attacks in patients with heart disease is stent implantation in the diseased coronary artery. Whilst this procedure has revolutionised treatment the incidence of secondary events remains a concern. These repeat events are due in part to continued enhanced platelet reactivity, endothelial dysfunction and a phenomenon called 'restenosis' i.e. the stent becomes blocked ultimately requiring another expensive and risky procedure. In this study it will be determined whether a once daily inorganic nitrate administration might favourably modulate platelet reactivity and endothelial function leading to a decrease in restenosis.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Rethinking Endothelial Dysfunction as a Crucial Target in Fighting Heart Failure.
Premer C, Kanelidis AJ, Hare JM, Schulman IH. · · 2019 · cited 78× · PMID 30899903 · DOI 10.1016/j.mayocpiqo.2018.12.006 -
Randomised, double-blind, placebo-controlled study investigating the effects of inorganic nitrate on vascular function, platelet reactivity and restenosis in stable angina: protocol of the NITRATE-OCT study.
Rathod KS, Jones DA, Van-Eijl TJ, Tsang H, et al · · 2016 · cited 5× · PMID 27998900 · DOI 10.1136/bmjopen-2016-012728 -
The NITRATE-OCT study-inorganic nitrate reduces in-stent restenosis in patients with stable coronary artery disease: a double-blind, randomised controlled trial.
Rathod KS, Mathur A, Shabbir A, Khambata RS, et al · · 2024 · cited 4× · PMID 39469537 · DOI 10.1016/j.eclinm.2024.102885
Verify or expand the search:
- PubMed search for NCT02529189
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Queen Mary University of London trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02529189 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Queen Mary University of London
- Last refreshed: 11 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02529189.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing