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NCT02516111
Comparative Evaluation of Autologous PRF, 1% Alendronate and 1.2% Atorvastatin Gel in Treatment of 2/3-walled Intrabony Defects in Chronic Periodontitis Subjects: a Randomized Controlled Clinical Trial
Phase 2/Phase 3 trial testing Open flap debridement (OFD) in Chronic Periodontitis in 120 participants. Completed in 1 May 2015.
1 May 2015
Quick facts
| Lead sponsor | Government Dental College and Research Institute, Bangalore |
|---|---|
| Phase | Phase 2/Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 120 |
| Start date | 1 September 2014 |
| Primary completion | 1 May 2015 |
| Estimated completion | 1 May 2015 |
Drugs / interventions tested
- Open flap debridement (OFD)
- OFD with PRF — full drug profile →
- OFD with ALN — full drug profile →
- OFD with ATV — full drug profile →
Conditions studied
- Chronic Periodontitis — all drugs for Chronic Periodontitis →
Sponsor
Government Dental College and Research Institute, Bangalore
Who can join
Adults 30 to 50, female only, with Chronic Periodontitis. Healthy volunteers can join.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
defect depth reduction (DDR)
Time frame: Change from baseline to 9 months
Sponsor's own description
The present study is designed as a single-centre, randomized, controlled clinical trial to evaluate and compare the clinical efficacy of autologous PRF, 1% alendronate (ALN) and 1.2% atorvastatin (ATV) gel placement with open flap debriedement in treatment of intrabony defects in patients with chronic periodontitis.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT02516111
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Chronic Periodontitis
Currently open trials in the same condition.
- NCT06893107 — Study on Treatment Results and Bone Changes After Replanting Severely Affected Teeth - A Before-and-After Study. · NA · recruiting
- NCT05275192 — Utilization of a Videoscope in Periodontal Regeneration · NA · recruiting
- NCT03741374 — Minimally-invasive Non-surgical Therapy of Intrabony Defects · NA · active not recruiting
- NCT03553095 — Comparing Inflammatory Markers in Patients With and Without Depression With Chronic Periodontitis · NA · active not recruiting
Other Government Dental College and Research Institute, Bangalore trials
Trials by the same sponsor.
- NCT03738514 — Comparison of Efficacy of 5% Fluorocalcium Phosphosilicate Dentifrice and Potassium Nitrate Dentifrice on Dentinal Hyper · Phase 2 · completed
- NCT03741309 — Comparison of Clinical Efficacy of a Dentifrice Containing 5% Fluoro Calcium Phosphosilicate to a Dentifrice Containing · Phase 2 · completed
- NCT03745300 — Comparative Evaluation Of 1.2% Atorvastatin and 1.2% Simvastatin Gel Local Drug Delivery And Redelivery In Chronic Perio · Phase 2, PHASE3 · completed
- NCT03204058 — Locally Delivered Metformin & Rosuvastatin for Treatment of Intrabony Defects in Chronic Periodontitis · Phase 2, PHASE3 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02516111 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Government Dental College and Research Institute, Bangalore
- Last refreshed: 4 August 2015
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02516111.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing