NCT02511574 (PAP-C) is a Phase 4 clinical trial of natural progesterone in Preterm Labor, sponsored by University of Sao Paulo.

Who is sponsoring NCT02511574?

NCT02511574 is sponsored by University of Sao Paulo.

What drugs are being tested in NCT02511574?

Interventions in NCT02511574: natural progesterone, cervical pessary.

What condition does NCT02511574 study?

NCT02511574 studies Preterm Labor, Premature Birth.

Is NCT02511574 still recruiting?

NCT02511574 is currently completed. Last updated 19 March 2026.

Last reviewed 2026-03-19 · How we verify

NCT02511574: PAP-C

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparison Between Natural Progesterone and Vaginal Pessary for the Prevention of Spontaneous Preterm Birth

Completed Phase 4 Last updated 19 March 2026

What this trial tests

Phase 4 trial testing natural progesterone in Preterm Labor in 203 participants. Completed in 30 August 2023.

Timeline

3 August 2015

Primary endpoint
10 December 2022

30 August 2023

Quick facts

Lead sponsor	University of Sao Paulo
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	203
Start date	3 August 2015
Primary completion	10 December 2022
Estimated completion	30 August 2023
Sites	1 location across Brazil

Drugs / interventions tested

natural progesterone — full drug profile →
cervical pessary

Conditions studied

Preterm Labor — all drugs for Preterm Labor →
Premature Birth — all drugs for Premature Birth →

Sponsor

University of Sao Paulo

Who can join

Eligibility, female only, with Preterm Labor or Premature Birth. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of this study is to compare the effectiveness between the cervical pessary and the natural progesterone in reduction of preterm birth rates in pregnant women with a uterine cervical length of 25 mm or less evaluated by transvaginal ultrasonography.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Cervical pessary for preventing preterm birth in singleton pregnancies.
Abdel-Aleem H, Shaaban OM, Abdel-Aleem MA, Aboelfadle Mohamed A. · · 2022 · cited 10× · PMID 36453699 · DOI 10.1002/14651858.cd014508
Women's Obstetric History and Midtrimester Cervical Length Measurements by 2D/3D and Doppler Ultrasound.
Marinelli JVC, Filho AGA, de Barros MF, Rodrigues AS, et al · · 2020 · cited 3× · PMID 32575132 · DOI 10.1055/s-0040-1713010
Vaginal Microbiota in Short Cervix Pregnancy: Secondary Analysis of Pessary vs. Progesterone Trial.
Amorim Filho AG, Martins RCR, Franco LAM, Marinelli JVC, et al · · 2025 · PMID 41149072 · DOI 10.3390/diseases13100338

Verify or expand the search:

Other recruiting trials for Preterm Labor

Currently open trials in the same condition.

NCT07015203 — The Combined First Trimester Screening · recruiting
NCT07263490 — PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients) · recruiting
NCT06053697 — Is the Vaginal Microbiome and Metabolome Associated With Spontaneous Preterm Birth (sPTB) in Multiple Pregnancies? · active not recruiting
NCT05698966 — Low Dose Antenatal Corticosteroids for Late Preterm Delivery · NA · recruiting
NCT06074601 — MIRACLE of LIFE Study · active not recruiting

Other University of Sao Paulo trials

Trials by the same sponsor.

NCT07463859 — Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabet · NA · recruiting
NCT07522554 — Lavender and Lemongrass Aromatherapy for Pain and Anxiety in Labor: A Randomized Trial · NA · active not recruiting
NCT07479940 — Obesity and Aging: Impacts of Nutritional Counseling and Physical Exercise on Telomeres and Senescence Parameters · NA · active not recruiting
NCT07445178 — Piecemeal Resection and Advanced Histology Independently Predict Local Recurrence After Colorectal Snare-based Endoscopi · completed
NCT07170007 — Physiotherapeutic Protocol Compared to Usual Care in the Treatment of Primiparas After Perineal Trauma · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02511574 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Sao Paulo
Last refreshed: 19 March 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02511574.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing