Surrogate Markers of Portal Pressure and Changes in Portal Pressure in Patients With Compensated Cirrhosis Undergoing Anti-viral Therapy

NCT02508298 NA COMPLETED

This is a prospective longitudinal study that will evaluate if changes (pre and post therapy) in indocyanine green (ICG) retention test and liver stiff ness (LS) and spleen stiffness (SS) as measured by acoustic radiofrequency impulse (ARFI) correlate with changes in portal pressure as determined by the hepatic vein pressure gradient (HVPG) in patients with compensated hepatitis C virus (HCV) cirrhosis undergoing antiviral therapy.

Details

Lead sponsor	VA Connecticut Healthcare System
Phase	NA
Status	COMPLETED
Enrolment	41
Start date	2014-04
Completion	2019-07

Conditions

• Portal Hypertension
• Cirrhosis

Interventions

• HVPG
• Indocyanine Green Retention test
• Liver stiffness measurement
• Spleen stiffness measurement

Primary outcomes

• Indocyanine Green before and after treatment of hepatitis c — 2 years
  Indocyanine Green will be obtained , this will be conducted before and after treatment for hepatitis c and is measured in mg/dl

Countries

United States