NCT02504840

Natural History of Multiple Sclerosis and Its Mimickers

Completed Last updated 14 October 2022

What this trial tests

trial in Neurologic Disorders in 104 participants. Completed in 5 March 2020.

Timeline

23 July 2015

Primary endpoint
5 March 2020

5 March 2020

Quick facts

Lead sponsor	National Institute of Neurological Disorders and Stroke (NINDS)
Status	Completed
Study type	OBSERVATIONAL
Enrollment	104
Start date	23 July 2015
Primary completion	5 March 2020
Estimated completion	5 March 2020
Sites	1 location across United States

Conditions studied

• Neurologic Disorders — all drugs for Neurologic Disorders →
• Healthy Volunteers — all drugs for Healthy Volunteers →
• Multiple Sclerosis — all drugs for Multiple Sclerosis →

Sponsor

National Institute of Neurological Disorders and Stroke (NINDS)

Who can join

18 and older, any sex, with Neurologic Disorders or Healthy Volunteers. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background:

\- Magnetic resonance imaging (MRI) has been used for decades to help diagnose and monitor neurological disorders like multiple sclerosis (MS). Researchers want to improve how MRI pictures are taken. They also want to learn more about using newer MRIs with stronger magnets to get better pictures than standard MRIs provide.

Objectives:

\- To collect data that will help researchers better understand MS and related diseases.

Eligibility:

* Adults 18 and older with MS or MRI findings that appear similar to MS, or with other neurological diseases that may look or act like MS.
* Healthy adult volunteers.

Design:

* Participants will be screened with a review of their medical records.
* Participants will have a baseline visit. It will include a physical exam, medical history, and neurological exam. They may have blood tests.
* The study will last indefinitely.
* Participants may have MRIs. Some MRIs may include a contrast dye. For this, a needle will be used to guide a thin plastic tube into an arm vein.
* Participants may have up to 2 lumbar punctures per year. Skin will be numbed and a needle inserted between back bones will remove fluid.
* Participants may give saliva samples and have an eye exam.
* Participants may have evoked potential tests. These measure how the nervous system responds to different types of stimulation. Participants may sit in front of a TV and watch pictures on the screen. Or they may wear earphones that make a clicking noise or static. Or they may get a small electrical shock that may tingle and cause a hand or foot twitch.
* Participants may have tests of strength, spasticity, sensations, balance, and/or walking.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI.
   Absinta M, Ha SK, Nair G, Sati P, et al · · 2017 · cited 481× · PMID 28971799 · DOI 10.7554/elife.29738