NCT02486328 is a Phase 4 clinical trial of Midazolam in Gastrointestinal Dysfunction, sponsored by Ufuk University.

Who is sponsoring NCT02486328?

NCT02486328 is sponsored by Ufuk University.

What drugs are being tested in NCT02486328?

Interventions in NCT02486328: Midazolam, Meperidine, Remifentanil, Propofol.

What condition does NCT02486328 study?

NCT02486328 studies Gastrointestinal Dysfunction, Alteration of Cognitive Function.

Is NCT02486328 still recruiting?

NCT02486328 is currently completed. Last updated 18 August 2020.

Are results published for NCT02486328?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2020-08-18 · How we verify

NCT02486328

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effect of Different Sedation Regimes Administered by Anesthesiologists or Endoscopists on Cognitive Functions in Lower Gastrointestinal System Endoscopy

Completed Phase 4 Results posted Last updated 18 August 2020

What this trial tests

Phase 4 trial testing Midazolam in Gastrointestinal Dysfunction in 103 participants. Completed in 1 June 2015.

Timeline

1 May 2015

Primary endpoint
1 June 2015

1 June 2015

Quick facts

Lead sponsor	Ufuk University
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	diagnostic
Enrollment	103
Start date	1 May 2015
Primary completion	1 June 2015
Estimated completion	1 June 2015

Drugs / interventions tested

Midazolam (midazolam) — full drug profile →
Meperidine — full drug profile →
Remifentanil — full drug profile →
Propofol (Propofol) — full drug profile →

Conditions studied

Gastrointestinal Dysfunction — all drugs for Gastrointestinal Dysfunction →
Alteration of Cognitive Function — all drugs for Alteration of Cognitive Function →

Sponsor

Ufuk University

Who can join

Adults 18 to 65, any sex, with Gastrointestinal Dysfunction or Alteration of Cognitive Function. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Change in Cognitive Function
Time frame: Baseline and 5, 15, 30 minutes after the procedure
As measured by Trieger Dot Test. The test does not have an upper limit; the time taken to complete the test is added to the number of dots missed by the patient and a result is obtained. The lowest score possible is 0. Higher values represent worse outcomes.
Change in Cognitive Function
Time frame: Baseline and 5, 15, 30 minutes after the procedure
As measured by Digit Symbol Substitution Test. Scale range 0-9. No cut-off value. Higher results represent better outcomes

Sponsor's own description

There are different sedation regimes for lower gastrointestinal system endoscopy which can be administered by anesthesiologists and non-anesthesiologists. This study aims to compare the effects of propofol/remifentanil combination and midazolam/meperidine combination on early cognitive function following lower gastrointestinal system endoscopies.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Effect of Different Sedation Regimes on Cognitive Functions in Colonoscopy.
Ekmekçi P, Erkan G, Yilmaz H, K Kazbek B, et al · · 2017 · cited 8× · PMID 29201800 · DOI 10.5005/jp-journals-10018-1239

Verify or expand the search:

Other trials of Midazolam

Trials testing the same drug.

NCT05945147 — Ketamine and Midazolam Infusions for CRPS: Feasibility Study · Phase 2 · withdrawn
NCT07525544 — A Study to Investigate the Safety and PK of VH4770359 in Healthy Participants · Phase 1 · not yet recruiting
NCT07426757 — An Open-Label Study to Evaluate PF-07994525 in Participants With Advanced Cancers · Phase 1 · not yet recruiting
NCT07435194 — A Clinical Trial in Healthy Participants to Learn How Itraconazole Affects MK-2828 Levels and How MK-2828 Affects Midazo · Phase 1 · recruiting
NCT07443254 — Prospective IR-led Sedation Feasibility · Phase 1, PHASE2 · recruiting

Other recruiting trials for Gastrointestinal Dysfunction

Currently open trials in the same condition.

NCT07252102 — Effect of HFNC on Incidence of Hypoxia During Sedated Gastrointestinal Endoscopy in Critical Patients · NA · recruiting
NCT06510348 — Achieving nuTritional Target in criticAlly Ill patieNts With iMpairEd gastroiNtesTinal Dysfunction · NA · recruiting
NCT06740903 — Evaluating Perioperative Outcomes: Dexmedetomidine vs Lignocaine in Laparoscopic Chlolecystectomy · Phase 2, PHASE3 · recruiting
NCT06386471 — Personalized GI Motility Responses to Diet · NA · recruiting
NCT05344417 — Low Pressure Pneumoperitoneum and Postoperative Ileus · NA · recruiting

Other Ufuk University trials

Trials by the same sponsor.

NCT07320157 — The Effect of HPV Education Provided to Women on Their Knowledge Levels, HPV Screening, and Vaccination Uptake · NA · recruiting
NCT07189247 — Evaluation of Fibromyalgia Frequency and Pain Parameters in Women With Polycystic Ovary Syndrome · not yet recruiting
NCT06821204 — Detection of Pathogenic Bacteria in Make-up Tools · NA · completed
NCT06606834 — Assessment of the Uterus Using Ultrasonographic Elastography in Women with Dysmenorrhea · not yet recruiting
NCT06624722 — Postural Habits, Awareness and Spine · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02486328 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ufuk University
Last refreshed: 18 August 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02486328.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing