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NCT02483806
Effects of Positive End-Expiratory Pressure on Biventricular Function During One-Lung Ventilation
NA trial testing PEEP in Lung Cancer in 36 participants. Completed in 25 May 2016.
25 May 2016
Quick facts
| Lead sponsor | Yonsei University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | diagnostic |
| Enrollment | 36 |
| Start date | 29 June 2015 |
| Primary completion | 25 May 2016 |
| Estimated completion | 25 May 2016 |
| Sites | 1 location across South Korea |
Drugs / interventions tested
- PEEP
Conditions studied
- Lung Cancer — all drugs for Lung Cancer →
Sponsor
Yonsei University
Who can join
Adults 40 to 80, any sex, with Lung Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
One lung ventilation (OLV) is essential during thoracic surgery. During OLV, intrapulmonary shunt can be increased resulting hypoxemia. Wang et al measured intrapulmonary shunt by transesophageal echocardiography. Although OLV technique had been advanced so far, hypoxemia during OLV reaches about 10% in spite of inspired oxygen fraction 100%. Applying PEEP(Positive End-expiratory Pressure) at dependent lung and CPAP at non-dependent lung can mitigate the hypoxemia. Above all, PEEP can be easily applicable. However, there are controversial studies whether it is supportive or not. In this prospective, cross-over study, the investigators are planning to investigate the effects of PEEP on intrapulmonary shunt, oxygenation and cardiac function as well.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effects of Positive End-Expiratory Pressure on Pulmonary Oxygenation and Biventricular Function during One-Lung Ventilation: A Randomized Crossover Study.
Kim N, Lee SH, Choi KW, Lee H, et al · · 2019 · cited 4× · PMID 31126111 · DOI 10.3390/jcm8050740
Verify or expand the search:
- PubMed search for NCT02483806
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of PEEP
Trials testing the same drug.
- NCT06654778 — Ultrasound Evaluation of Preventive Measures for Postoperative Lung Atelectasis After Surgery · NA · completed
- NCT06270485 — Influence of Positive-End-Expiratory-Pressure (PEEP) on Cardiac Output in Mechanically Ventilated Children · NA · completed
- NCT05691205 — Identifying Optimal PEEP After Lung Transplantation · NA · completed
- NCT05275283 — Efficacy Evaluation of Positive End-expiratory Pressure in Children Undergoing Mechanical Ventilation Using Supraglottic · NA · unknown
- NCT04853563 — Comparison of PEEP in Acute Decompensated Heart Failure · NA · unknown
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Currently open trials in the same condition.
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Other Yonsei University trials
Trials by the same sponsor.
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- NCT07507188 — Collaborative Clinical-translational Cohort of Amivantamab Plus Lazertinib and Amivantamab Plus Chemotherapy in Patients · Phase 2 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02483806 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Yonsei University
- Last refreshed: 28 December 2017
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02483806.
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