Comparison of Remifentanil and Dexmedetomidine for Monitored Anaesthesia Care

NCT02476981 NA COMPLETED

This randomised, double-blind study compared remifentanil and dexmedetomidine for monitored anaesthesia care (MAC) during minimally invasive corrections of vertebral compression fracture (vertebroplasty (VP) and kyphoplasty (KP)). In total, 80 ASA physical status I-III patients scheduled for VP and KP randomly received remifentanil or dexmedetomidine to maintain OAA/S scale ≤ 4 during the procedures. Multiple hemodynamic variables of patients were recorded and the frequency of oxygen desaturation, respiratory depression, intraoperative need for other opioids, recovery time, operator satisfaction score, and patients' overall pain experiences were also compared. The investigators are expecting that both remifentanil and dexmedetomidine appear to be quite safe for MAC during VP and KP. Thus, dexmedetomidine may be an alternative for MAC during VP and KP in elderly patients.

Details

Lead sponsor	Hallym University Medical Center
Phase	NA
Status	COMPLETED
Enrolment	75
Start date	2012-08
Completion	2014-10

Conditions

• Fractures, Compression

Interventions

• Remifentanil
• Dexmedetomidine
• midazolam
• propofol
• ephedrine

Primary outcomes

• The frequencies of oxygen desaturation during procedures — About 1 hour through the procedures

Countries

South Korea