Last reviewed · How we verify
NCT02476396
Structural Stability of Carotid Plaque and Symptomatology
trial testing Carotid Endarterectomy or Stenting in Carotid Stenosis in 176 participants. Completed in 14 July 2024.
14 July 2024
Quick facts
| Lead sponsor | University of Wisconsin, Madison |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 176 |
| Start date | 9 November 2015 |
| Primary completion | 14 July 2024 |
| Estimated completion | 14 July 2024 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Carotid Endarterectomy or Stenting
Conditions studied
- Carotid Stenosis — all drugs for Carotid Stenosis →
- Stroke — all drugs for Stroke →
- Carotid Artery Plaque — all drugs for Carotid Artery Plaque →
- Transient Ischemic Attack — all drugs for Transient Ischemic Attack →
Sponsor
University of Wisconsin, Madison
Who can join
18 and older, any sex, with Carotid Stenosis or Stroke. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of the research is to understand structural plaque abnormalities that make a carotid plaque unstable and brake off (embolize) which would help to predict and treat individuals who are likely to suffer not only classic episodic major strokes but also cognitive impairment.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Histopathologic Validation of Grayscale Carotid Plaque Characteristics Related to Plaque Vulnerability.
Mitchell CC, Stein JH, Cook TD, Salamat S, et al · · 2017 · cited 54× · PMID 27720278 · DOI 10.1016/j.ultrasmedbio.2016.08.011 -
Carotid atherosclerotic plaque instability and cognition determined by ultrasound-measured plaque strain in asymptomatic patients with significant stenosis.
Dempsey RJ, Varghese T, Jackson DC, Wang X, et al · · 2018 · cited 50× · PMID 28298048 · DOI 10.3171/2016.10.jns161299 -
The Preservation of Cognition 1 Year After Carotid Endarterectomy in Patients With Prior Cognitive Decline.
Dempsey RJ, Jackson DC, Wilbrand SM, Mitchell CC, et al · · 2018 · cited 22× · PMID 28575478 · DOI 10.1093/neuros/nyx173
Verify or expand the search:
- PubMed search for NCT02476396
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Carotid Stenosis
Currently open trials in the same condition.
- NCT07412249 — Remote Ischemic Conditioning Plus Stenting for Symptomatic Carotid Artery Stenosis · NA · recruiting
- NCT07057297 — Residual Stenosis and Restenosis Following Carotid Endarterectomy With Primary Closure, A Prospective Tracking Study · recruiting
- NCT06546761 — Selective Coronary Revascularization in Carotid Artery Disease Patients After Carotid Revascularization (SCORECAD Trial) · recruiting
- NCT06986330 — Endovascular Treatment of Cerebrovascular Diseases Guided by Optical Coherence Tomography (OCT) Technology（CVD-OCT） · active not recruiting
- NCT06485102 — Differences of the Postoperative Outcome for Carotid Surgery Patients Treated by Either Male or Female Surgeons · active not recruiting
Other University of Wisconsin, Madison trials
Trials by the same sponsor.
- NCT07440004 — Testing a Digital Mindfulness Program to Support People Experiencing Suicidal Thoughts · Phase 1 · recruiting
- NCT07278466 — The COMParing App Support Strategies Study · NA · recruiting
- NCT07475104 — Redesigning Surgical Care for Patients in Wisconsin · NA · enrolling by invitation
- NCT07470723 — The ORIGIN-FH Study · NA · recruiting
- NCT06975657 — Well-being Skills for Reentry · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02476396 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Wisconsin, Madison
- Last refreshed: 16 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02476396.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing