Last reviewed · How we verify
Health Evaluation in African Americans Using RAS Therapy (HEART)
The purpose of this study is to determine if telmisartan, an FDA approved blood pressure medication, may also have beneficial effects on Alzheimer's disease prevention in African Americans, who are at high risk for Alzheimer's disease.
Details
| Lead sponsor | Emory University |
|---|---|
| Phase | Phase 1/Phase 2 |
| Status | COMPLETED |
| Enrolment | 61 |
| Start date | 2015-04 |
| Completion | 2022-04-15 |
Conditions
- Alzheimer's Disease
Interventions
- Telmisartan 20mg
- Telmisartan 40mg
- Placebo
Primary outcomes
- Concentration of Angiotensin Converting Enzyme (ACE 1) — Baseline, Month 8
The cerebrospinal fluid renin-angiotensin system (RAS) was assessed by measuring levels of angiotensin metabolites in a 1 milliliter (mL) sample of cerebrospinal fluid (CSF). ACE 1 helps to regulate blood pressure by converting angiotensin I to angiotensin II. - Concentration of Angiotensin Converting Enzyme 2 (ACE 2) — Baseline, Month 8
The cerebrospinal fluid renin-angiotensin system (RAS) was assessed by measuring levels of angiotensin metabolites in a 1 milliliter (mL) sample of cerebrospinal fluid (CSF). ACE 2 regulates levels of circulating angiotensin II. ACE 2 increases during illness and with Alzheimer's disease. - Cerebrospinal Fluid Amyloid β40 — Baseline, Month 8
Levels of amyloid β40 (Aβ40) in the cerebrospinal fluid were measured using LUMIPULSE® technology. The relationship between Aβ40 is non-linear with moderate levels showing the highest risk of future cognitive decline in some studies. - Levels of Cerebrospinal Fluid Amyloid β42 — Baseline, Month 8
Levels of amyloid β42 (Aβ42) in the cerebrospinal fluid were measured using LUMIPULSE® technology. Decreases in concentrations of amyloid β42 are indicative of a decrease in cognitive function. - Levels of Cerebrospinal Fluid T-tau — Baseline, Month 8
Levels of T-tau in the cerebrospinal fluid were measured using LUMIPULSE® technology. Increases in concentrations of T-tau are indicative of a decrease in cognitive function. - Levels of Cerebrospinal Fluid P-tau — Baseline, Month 8
Levels of P-tau in the cerebrospinal fluid were measured using LUMIPULSE® technology. Increases in concentrations of P-tau are indicative of a decrease in cognitive function.
Countries
United States