50 and older, any sex, with Macular Degeneration. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Percentage of Participants With Stable Vision at Week 52Primary· Baseline to Week 52
Stable vision was defined as a loss of fewer than 15 letters in BCVA compared to baseline. BCVA was measured using an eye chart and reported as the number of letters read correctly using the Early Treatment of Diabetic Retinopathy Study (ETDRS) Scale (ranging from 0 to 100 letters) in the study eye. The lower the number of letters read correctly on the eye chart, the worse the vision (or visual acuity). An increase in the number of letters read correctly means that vision has improved. The percentage of participants with a BCVA loss of fewer than 15 letters are reported. The study eye is defin
Group
Value
95% CI
Abicipar Pegol 2 mg (2Q8)
91.7
Abicipar Pegol 2 mg (2Q12)
91.2
Ranibizumab 0.5 mg (rQ4)
95.5
Mean Change From Baseline in BCVA in the Study Eye at Week 52Secondary· Baseline to Week 52
BCVA was measured using an eye chart and was reported as the number of letters read correctly using the ETDRS Scale (ranging from 0 to 100 letters) in the study eye. The lower the number of letters read correctly on the eye chart, the worse the vision (or visual acuity). An increase in the number of letters read correctly means that vision has improved. The study eye is defined as the eye that meets the entry criteria. If both eyes met the entry criteria, the eye with the worse BCVA at baseline (Day 1) was selected as the study eye. If both eyes had same BCVA values at baseline (Day 1), then t
Group
Value
95% CI
Abicipar Pegol 2 mg (2Q8)
6.7
± 12.9
Abicipar Pegol 2 mg (2Q12)
5.6
± 13.3
Ranibizumab 0.5 mg (rQ4)
8.5
± 13.6
Mean Change From Baseline in Central Retinal Thickness (CRT) in the Study Eye at Week 52Secondary· Baseline to Week 52
CRT was assessed using spectral domain optical coherence tomography (SD-OCT), a non-invasive diagnostic system providing high-resolution imaging sections of the retina. SD-OCT was performed in the study eye after pupil dilation. A negative change from Baseline indicated improvement. The study eye is defined as the eye that meets the entry criteria. If both eyes met the entry criteria, the eye with the worse BCVA at baseline (Day 1) was selected as the study eye. If both eyes had same BCVA values at baseline (Day 1), then the participant had to select their non-dominant eye for treatment, or el
Group
Value
95% CI
Abicipar Pegol 2 mg (2Q8)
-141.5
± 136.4
Abicipar Pegol 2 mg (2Q12)
-150.1
± 127.4
Ranibizumab 0.5 mg (rQ4)
-141.3
± 122.0
Percentage of Participants With a Gain of 15 or More ETDRS Letters in BCVA From Baseline in Study Eye at Week 52Secondary· Baseline to Week 52
BCVA was measured using an eye chart and reported as the number of letters read correctly using the ETDRS Scale (ranging from 0 to 100 letters) in the study eye. The lower the number of letters read correctly on the eye chart, the worse the vision (or visual acuity). An increase in the number of letters read correctly means that vision has improved. The study eye is defined as the eye that meets the entry criteria. If both eyes met the entry criteria, the eye with the worse BCVA at baseline (Day 1) was selected as the study eye. If both eyes had same BCVA values at baseline (Day 1), then the p
Group
Value
95% CI
Abicipar Pegol 2 mg (2Q8)
22.6
Abicipar Pegol 2 mg (2Q12)
19.2
Ranibizumab 0.5 mg (rQ4)
27.2
Mean Change From Baseline in the National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ-25) Composite Score in Study Eye at Week 52Secondary· Baseline to Week 52
NEI-VFQ-25 consists of 25 vision-targeted questions that represent 11 vision-related quality of life subscales and one general health item. Responses of individual participants were recorded as scores that ranged between 0 (worst) to 100 (best vision related function) with higher scale indicating better vision related function. The overall composite score is then calculated by averaging over all 11 vision-targeted subscale scores, excluding the general health score. Overall composite score was calculated based on mean of non-missing subscales. Study eye was defined as eye that meets entry crit
Group
Value
95% CI
Abicipar Pegol 2 mg (2Q8)
2.7
± 0.7
Abicipar Pegol 2 mg (2Q12)
3.7
± 0.7
Ranibizumab 0.5 mg (rQ4)
4.6
± 0.7
Adverse events — posted to ClinicalTrials.gov
Time frame: From first dose to last dose of study drug (Up to Week 104).
Reporting threshold: 5%.
Adverse-event reports describe events observed during the trial — not all are caused by the drug.
NCT02462486 — Safety and Efficacy of Abicipar Pegol in Participants With Neovascular Age-related Macular Degeneration
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Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Allergan
Last refreshed: 28 July 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02462928.