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NCT02454777

High-Intensity Interval Training for Stage I-III Breast Cancer Patients

Terminated NA Last updated 5 April 2021
What this trial tests

NA trial testing Exercise Intervention in Stage IA Breast Cancer in 31 participants. Terminated before completion.

Timeline
29 September 2015
Primary endpoint
15 July 2019
15 July 2019

Quick facts

Lead sponsorUniversity of Southern California
PhaseNA
StatusTerminated
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingnone
Primary purposesupportive care
Enrollment31
Start date29 September 2015
Primary completion15 July 2019
Estimated completion15 July 2019
Sites1 location across United States

Drugs / interventions tested

Conditions studied

Sponsor

University of Southern California

Who can join

18 and older, female only, with Stage IA Breast Cancer or Stage IB Breast Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This randomized pilot clinical trial studies the feasibility of high-intensity interval training in improving cardiovascular fitness in patients with stage I-III breast cancer undergoing chemotherapy with trastuzumab. Trastuzumab helps patients live longer, but may cause side effects to the heart. Aerobic exercise may help the heart function better, which may help protect it against side effects from trastuzumab. Exercise may also help reduce fatigue and prevent cancer from coming back. High-intensity interval training involves short bursts of higher intensity efforts with longer periods of recovery. This may also allow patients who cannot exercise for a long period of time to still be physically active. This trial studies whether patients can tolerate high-intensity interval training, and how well it works in improving fitness in patients with breast cancer receiving trastuzumab.

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Feasibility of high intensity interval training in patients with breast Cancer undergoing anthracycline chemotherapy: a randomized pilot trial.
    Lee K, Kang I, Mack WJ, Mortimer J, et al · · 2019 · cited 58× · PMID 31269914 · DOI 10.1186/s12885-019-5887-7
  2. Effects of high-intensity interval training on vascular endothelial function and vascular wall thickness in breast cancer patients receiving anthracycline-based chemotherapy: a randomized pilot study.
    Lee K, Kang I, Mack WJ, Mortimer J, et al · · 2019 · cited 38× · PMID 31236810 · DOI 10.1007/s10549-019-05332-7
  3. Preventive Cardio-Oncology: The Time Has Come.
    Brown SA. · · 2019 · cited 35× · PMID 31998754 · DOI 10.3389/fcvm.2019.00187
  4. Exercise interventions for people undergoing multimodal cancer treatment that includes surgery.
    Loughney LA, West MA, Kemp GJ, Grocott MP, et al · · 2018 · cited 29× · PMID 30536366 · DOI 10.1002/14651858.cd012280.pub2
  5. Effect of high-intensity interval training on patient-reported outcomes and physical function in women with breast cancer receiving anthracycline-based chemotherapy.
    Lee K, Norris MK, Wang E, Dieli-Conwright CM. · · 2021 · cited 28× · PMID 34018031 · DOI 10.1007/s00520-021-06294-7
  6. Effects of high-intensity interval training on vascular function in breast cancer survivors undergoing anthracycline chemotherapy: design of a pilot study.
    Lee K, Kang I, Mortimer JE, Sattler F, et al · · 2018 · cited 13× · PMID 29961039 · DOI 10.1136/bmjopen-2018-022622
  7. Effect of High Intensity Interval Training on Matrix Metalloproteinases in Women with Breast Cancer Receiving Anthracycline-Based Chemotherapy.
    Lee K, Kang I, Mack WJ, Mortimer J, et al · · 2020 · cited 12× · PMID 32246106 · DOI 10.1038/s41598-020-61927-x

Verify or expand the search:

Other trials of Exercise Intervention

Trials testing the same drug.

Other recruiting trials for Stage IA Breast Cancer

Currently open trials in the same condition.

Other University of Southern California trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02454777.

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