NCT02445937

PARTNER II: Improving Patient and Family Centered Care in Advanced Critical Illness

Completed NA Last updated 15 October 2019

What this trial tests

NA trial testing PARTNER II in Anxiety in 848 participants. Completed in 18 September 2019.

Timeline

1 June 2015

Primary endpoint
18 September 2019

18 September 2019

Quick facts

Lead sponsor	University of Pittsburgh
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	sequential
Masking	single
Primary purpose	supportive care
Enrollment	848
Start date	1 June 2015
Primary completion	18 September 2019
Estimated completion	18 September 2019
Sites	2 locations across United States

Drugs / interventions tested

• PARTNER II

Conditions studied

• Anxiety — all drugs for Anxiety →
• Depression — all drugs for Depression →

Sponsor

University of Pittsburgh

Who can join

18 and older, any sex, with Anxiety or Depression. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a stepped wedged randomized controlled trial comparing the PARTNER intervention with usual care in 5 Intensive Care Units. The overarching goal of this research project to ensure patient-centered decisions about the use of intensive treatments for patients with advanced critical illness. In a prior project, the investigators developed the PARTNER program (PAiring Re-engineered ICU Teams with Nurse-driven Education and OutReach), a 4-facet, team-based intervention that re-engineers how surrogates are supported in ICUs, including: 1) changing care "defaults" to ensure clinician-family meetings within 48 hours of enrollment and frequently thereafter; 2) protocolized, nurse-administered coaching and emotional support of surrogates before and during clinician-family meetings, 3) increased use of palliative care services for patients with a poor prognosis. The investigators propose to begin deployment of the PARTNER II program in the spring of 2015 enrolling 690 surrogate decision makers in 5 ICUs using a stepped wedge design. The investigators expect to achieve the following project goals:

1. To increase the patient-centeredness of end-of-life decisions, and to increase the quality of clinician-family communication.
2. To decrease the psychological burden on family members acting as surrogates.
3. To reduce total health care costs by decreasing the duration of use of burdensome, invasive treatments at the end of life.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

1. Interventions for interpersonal communication about end of life care between health practitioners and affected people.
   Ryan RE, Connolly M, Bradford NK, Henderson S, et al · · 2022 · cited 33× · PMID 35802350 · DOI 10.1002/14651858.cd013116.pub2
2. Prevalence of long-term decision regret and associated risk factors in a large cohort of ICU surrogate decision makers.
   Andersen SK, Butler RA, Chang CH, Arnold R, et al · · 2023 · cited 23× · PMID 36797793 · DOI 10.1186/s13054-023-04332-w
3. Information or education interventions for adult intensive care unit (ICU) patients and their carers.
   Lewis SR, Pritchard MW, Schofield-Robinson OJ, Evans DJ, et al · · 2018 · cited 11× · PMID 30316199 · DOI 10.1002/14651858.cd012471.pub2
4. Protocol for a randomised trial of an interprofessional team-delivered intervention to support surrogate decision-makers in ICUs.
   Lincoln T, Shields AM, Buddadhumaruk P, Chang CH, et al · · 2020 · cited 9× · PMID 32229520 · DOI 10.1136/bmjopen-2019-033521