An Investigation Into the Pressure and Airflow/Volume Changes Which Accompany Partial Closure of the Larynx During Expiration in Patients With COPD and the Effect of Applying a Positive End Expired Pressure by Facemask on These Parameters

NCT02437630 UNKNOWN

In this study the investigators aim to investigate the extent to which in patients with chronic obstructive pulmonary disease narrowing of the vocal cords causes a positive pressure within the airways thus improving airflow and lung function. This information will be captured in the upright and lying down positions and an estimate of the magnitude of the effect will be formed by offsetting the pressure by asking the patients to breathe using a commercially available device used to treat sleep apnoea called a CPAP machine. This is an observational study in which the observation of laryngeal aperture, and mouth and oesophageal pressure at differing levels of applied CPAP will be recorded for analysis in patients with COPD and in normal subjects without COPD. All will have the same measurements, observations, and interventions to allow us to observe and measure pressure, laryngeal aperture, and airflow .

Details

Lead sponsor	Royal Brompton & Harefield NHS Foundation Trust
Status	UNKNOWN
Enrolment	30
Start date	2016-04
Completion	2018-05

Conditions

• Chronic Obstructive Pulmonary Disease

Interventions

• Oesophageal balloon to measure intra-thoracic pressure
• Fibre-optic laryngoscopy
• standard lung function tests
• face mask CPAP
• variation of mouth pressure with CPAP
• facemask pneumotachograph

Primary outcomes

• We will measure glottic aperture and compare glottic aperture observed with different levels of applied EPAP (expiratory positive airway pressure)in the erect and supine positions — 2 years
  we will measure glottic aperture and compare glottic aperture observed with different levels of applied EPAP on glottic opening in the erect and supine positions

Countries

United Kingdom