A Randomized Clinical Trial on the Use of Sodium Fluoride Varnish and Silver Diamine Fluoride Solution for Arresting Active Dental Caries in Preschool Children

NCT02426619 Phase 2/Phase 3 COMPLETED

This randomized clinical trial aims to compare the effectiveness of three topical fluoride application protocols, namely three applications of a 30% SDF solution at yearly or weekly interval and three applications of a 5% NaF varnish at weekly interval, in arresting dental caries in the primary teeth of preschool children over 30 months.

Details

Lead sponsor	The University of Hong Kong
Phase	Phase 2/Phase 3
Status	COMPLETED
Enrolment	371
Start date	2012-09
Completion	2015-04

Conditions

• Dental Caries

Interventions

• SDF solution
• NaF varnish

Primary outcomes

• change in hardness of dental caries lesion — baseline and 30 months
  change from a soft active dental caries lesion at baseline to a hardened arrested caries lesion upon gentle probing with a dental explorer at the evaluation is regarded as a positive treatment outcome

Countries

China