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Analgesic Efficacy of Liposomal Bupivacaine in Total Knee Arthroplasty
Liposomal bupivacaine is a novel local anesthetic designed for prolonged pain relief. Despite its long-acting analgesic potential, liposomal bupivacaine is significantly more expensive than other local anesthetic alternatives. The primary aim of this investigation is to examine whether or not liposomal bupivacaine provides superior pain relief or clinically significant opioid-sparing effects versus a control to justify its cost.
Details
| Lead sponsor | Miller Orthopedic Specialists |
|---|---|
| Phase | Phase 4 |
| Status | WITHDRAWN |
| Start date | 2015-06 |
| Completion | 2017-06 |
Conditions
- Pain, Postoperative
- Arthroplasty, Replacement, Knee
- Osteoarthritis
Interventions
- Liposomal bupivacaine
- bupivacaine HCl, morphine, epinephrine, methylprednisolone
Primary outcomes
- Mean visual analog scale (VAS) pain scores — Night of surgery
Self-reported pain scores from 0=no pain to 10=severe pain - Mean visual analog scale (VAS) pain scores — Post-operative day 1
Self-reported pain scores from 0=no pain to 10=severe pain - Mean visual analog scale (VAS) pain scores — Post-operative day 2
Self-reported pain scores from 0=no pain to 10=severe pain - Pain assessment phone call — Post-operative day 3
Subjects will be called on post-operative day three by one of the investigators of the study. Subjects will be asked to rate their current pain level from 1 to 10 and to rate their worst pain level from 1 to 10 that day.
Countries
United States