The Effect of Parecoxib Sodium Intravenous Patient-controlled Analgesia in Laparotomic Liver Resection

NCT02408146 NA UNKNOWN

The investigators hypothesized that using new intravenous infusion pump of patient-controlled analgesia (parecoxib sodium 1 mg/mL + normal saline) would significantly improve postoperative pain control compare to conventional intravenous infusion pump of patient-controlled analgesia (fentanyl citrate 20 mg/mL/kg + ondansetron hydrochloride 16 mg/8 mL + normal saline). This prospective randomized controlled trial was designed to evaluate the benefit of new intravenous infusion pump of patient-controlled analgesia (parecoxib sodium 1 mg/mL + normal saline) for postoperative analgesia after laparotomic liver resection.

Details

Lead sponsor	First Affiliated Hospital of Harbin Medical University
Phase	NA
Status	UNKNOWN
Enrolment	80
Start date	2014-01

Conditions

• Pain, Postoperative

Interventions

• conventional intravenous infusion pump
• parecoxib
• intravenous infusion pump of patient-controlled analgesia
• fentanyl citrate+ ondansetron hydrochloride + normal saline
• celecoxib

Primary outcomes

• The measure is a composite outcome measure consisting of multiple measures,pain scores, sedation, nausea, pruritus, and respiratory rate. — With or without changes in the three days after surgery
  Pain scores are evaluated with a visual analog scale of 0 to 100 and are measured at rest and with movement such as cough or incentive spirometry at 6, 9, 12, 18, 24, 36, 48 and 72 hours. Sedation, nausea, and pruritus are also measured at 6, 9, 12, 18, 24, 36, 48 and 72 hours. All the measures count together to get a composite outcome.

Countries

China