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Role of Airway Tissue Temperature in Asthma Exacerbation (RATE)
Airway irritation, cough and bronchial spasm are common symptoms in patients with airway inflammatory diseases such as asthma. The primary focus of this exploratory study is to determine if there is an increase in tissue temperature in airway mucosa during asthma exacerbation. The results of this study will bring a better understanding of the potential involvement of an increase in airway mucosa temperature in the pathogenesis of various symptoms in these patients. The finding should help to advance the development of new therapeutic strategies for these debilitating diseases.
Details
| Lead sponsor | Lu Yuan Lee |
|---|---|
| Phase | Phase 1 |
| Status | WITHDRAWN |
| Start date | 2018-11-08 |
| Completion | 2020-06 |
Conditions
- Asthma
Interventions
- Segmental Bronchoprovocation with Allergen (SBP-Ag)
Primary outcomes
- Airway tissue temperature — Immediately during experimental procedure (up to 10 minutes)
Direct measurements of the airway mucosal temperature will be performed before and at ten minutes after the SBP-Ag challenge. By maneuvering the control knob of the bronchoscope, the blunted tip of the probe will be gently pressed against the airway mucosa at 5-6 different positions in segmental and sub-segmental bronchi, each for five to ten seconds. The entire protocol of the temperature measurement will require no more than 5 minutes to complete.
Countries
United States