NCT02391714 (NIUD) is a NA clinical trial of IUD insertion in Contraception, sponsored by University of New Mexico.

Who is sponsoring NCT02391714?

NCT02391714 is sponsored by University of New Mexico.

What drugs are being tested in NCT02391714?

Interventions in NCT02391714: IUD insertion, Povidone-Iodine, Chlorhexidine, Oxygen, Nitrous oxide.

What condition does NCT02391714 study?

NCT02391714 studies Contraception.

Is NCT02391714 still recruiting?

NCT02391714 is currently completed. Last updated 4 January 2016.

Are results published for NCT02391714?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2016-01-04 · How we verify

NCT02391714: NIUD

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Nitrous Oxide for Pain Management of Intrauterine Device Insertion

Completed NA Results posted Last updated 4 January 2016

What this trial tests

NA trial testing IUD insertion in Contraception in 80 participants. Completed in 1 August 2014.

Timeline

1 October 2013

Primary endpoint
1 August 2014

1 August 2014

Quick facts

Lead sponsor	University of New Mexico
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	80
Start date	1 October 2013
Primary completion	1 August 2014
Estimated completion	1 August 2014
Sites	1 location across United States

Drugs / interventions tested

IUD insertion
Povidone-Iodine — full drug profile →
Chlorhexidine (CHLORHEXIDINE) — full drug profile →
Oxygen — full drug profile →
Nitrous oxide (NITROUS OXIDE) — full drug profile →

Conditions studied

Contraception — all drugs for Contraception →

Sponsor

University of New Mexico

Who can join

12 and older, female only, with Contraception. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Mean Maximum Procedural Pain Scores
Time frame: 2 minutes after the procedure.
Pain is assessed using a 0-100mm VAS with anchors 0 equals no pain and 100 equals worst pain imaginable. The minimal clinically important difference in pain for this study was set at 15mm.

Sponsor's own description

The purpose of this study is to determine whether Nitrous Oxide is effective in achieving pain control and satisfaction among nulliparous women getting the intrauterine device (IUD).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

A randomized controlled trial of nitrous oxide for intrauterine device insertion in nulliparous women.
Singh RH, Thaxton L, Carr S, Leeman L, et al · · 2016 · cited 18× · PMID 27481016 · DOI 10.1016/j.ijgo.2016.04.014

Verify or expand the search:

Other trials of IUD insertion

Trials testing the same drug.

NCT04178031 — Association Between Clinical, Laboratory, Ultrasongraphy Predictors And Development of Copper IUD Complications · NA · completed

Other recruiting trials for Contraception

Currently open trials in the same condition.

NCT07365904 — Investigating Ovulation Inhibition for Use as a Contraceptive · Phase 2 · recruiting
NCT07437495 — Women's Knowledge of Contraception During the Postpartum Period · active not recruiting
NCT06823037 — Hormonal Contraception Access Through Pharmacist Prescribing Implementation · NA · recruiting
NCT07326007 — Verbal Analgesia Versus Standard Technique for Pain Control During Copper T380A Intrauterine Device Insertion in Women W · NA · recruiting
NCT05910580 — Improving Alcohol and Substance Use Care Access, Outcome, Equity During the Reproductive Years · NA · recruiting

Other University of New Mexico trials

Trials by the same sponsor.

NCT07484906 — Precision Phenotyping of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies · Phase 2 · withdrawn
NCT07506395 — Group Psilocybin-Assisted Therapy for Post-Traumatic Stress Disorder · Phase 1 · not yet recruiting
NCT07265973 — PREPARE: Perioperative REhabilitation Around Vaginal Prolapse RepAir Surgery for Recovery Enhancement · NA · recruiting
NCT06982443 — Wellness, Alcohol, Vitals, and Emotions · NA · recruiting
NCT06940609 — Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation · Phase 2 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02391714 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of New Mexico
Last refreshed: 4 January 2016

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02391714.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing