Who is sponsoring NCT02391519?

NCT02391519 is sponsored by University of Colorado, Denver.

What drugs are being tested in NCT02391519?

Interventions in NCT02391519: Collection of myometrial, cord blood, and placental tissue samples.

What condition does NCT02391519 study?

NCT02391519 studies Pregnancy, IUGR, Preeclampsia.

Is NCT02391519 still recruiting?

NCT02391519 is currently recruiting now. Last updated 10 February 2026.

Last reviewed 2026-02-10 · How we verify

NCT02391519

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effects of High Altitude on 5' Adenosine Monophosphate-activated Protein Kinase (AMPK) Activation and Peroxisome Proliferator-activated Receptor Gamma (PPARγ) Regulation

Recruiting now Last updated 10 February 2026

What this trial tests

trial testing Collection of myometrial, cord blood, and placental tissue samples in Pregnancy in 84 participants. Currently enrolling.

Timeline

1 January 2016

Primary endpoint
31 December 2026

31 December 2026

Quick facts

Lead sponsor	University of Colorado, Denver
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	84
Start date	1 January 2016
Primary completion	31 December 2026
Estimated completion	31 December 2026
Sites	1 location across United States

Drugs / interventions tested

Collection of myometrial, cord blood, and placental tissue samples

Conditions studied

Pregnancy — all drugs for Pregnancy →
IUGR — all drugs for IUGR →
Preeclampsia — all drugs for Preeclampsia →

Sponsor

University of Colorado, Denver

Who can join

Adults 18 to 45, female only, with Pregnancy or IUGR. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Changes in Myometrial artery dimensions
Time frame: Up to 1 year
Myometrial artery dimensions as quantified by immunohistochemistry or other staining techniques, and results of studies of isolated myometrial artery studies in which vasoconstrictor and vasodilator responses to pharmacological agonists are measured using absolute values and the percent maximal contraction to potassium chloride.

Sponsor's own description

Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth restriction (IUGR) and preeclampsia (PreE). The investigators propose to collect myometrial, cord blood, and placental tissue samples from women at high altitude (Summit County) and low altitude (Denver) in Colorado in order to determine if residence at altitude during pregnancy changes the vasoreactivity of myometrial arteries (MA). If altered MA vasoreactivity is found, further studies may be able to link these changes to the increased rates of PreE and IUGR at altitude and contribute to the understanding of these two disorders.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions.
Jin P, Duan X, Huang Z, Dong Y, et al · · 2025 · cited 21× · PMID 40717128 · DOI 10.1038/s41392-025-02270-3

Verify or expand the search:

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Other University of Colorado, Denver trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02391519 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Colorado, Denver
Last refreshed: 10 February 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02391519.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing