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On the Impact of Therapeutic Tumor Necrosis Factor-alpha Inhibition on Anogenital Human Papillomavirus Infection
In this prospective, open, controlled, cross-sectional observational study patients with psoriasis or IBD, who received either anti-TNF-alpha inhibitors or alternates (purine-, folic acid analogues, phototherapy, fumaric ester, mesalazine) for their underlying disease were included. Anogenital HPV-induced lesions, mucosal HPV DNA and serological status of mucosal low-risk (HPV6) and high-risk HPV (HPV16, HPV18) were determined.
Details
| Lead sponsor | Medical University of Vienna |
|---|---|
| Status | COMPLETED |
| Enrolment | 222 |
| Start date | 2009-12 |
| Completion | 2011-01 |
Conditions
- Psoriasis
- Inflammatory Bowel Diseases
Interventions
- TNF-alpha inhibitors
- Alternative/no medication
- Alternative/no medication
- Purine/folic acid analogues
Primary outcomes
- Number of anogenital warts, anogenital HPV DNA positivity and mucosal HPV seropositivity — 1 year