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Identification of New FTLD Genes (FTLD-Exome)
The major objective of the project is to map/identify new loci/genes, by a combination of whole exome sequencing and genome-wide linkage in autosomal dominant FTLD families excluded for known mutations. Several secondary goals will be attained in the course of during the project: For each novel gene identified in this project, we will determine the spectrum of mutations, evaluate their frequency and characterize the associated phenotypes. This will allow us to establish genotype-phenotype correlations in a large number of families, which will improve the nosology of these disorders and the diagnostic procedures;
Details
| Lead sponsor | Assistance Publique - Hôpitaux de Paris |
|---|---|
| Status | UNKNOWN |
| Enrolment | 440 |
| Start date | Mon Feb 02 2015 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Fri Feb 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Frontotemporal Lobar Degeneration
Countries
France