Who is sponsoring NCT02354677?

NCT02354677 is sponsored by University Hospital, Montpellier.

What drugs are being tested in NCT02354677?

Interventions in NCT02354677: In vitro experiments on bronchial epithelial cells.

What condition does NCT02354677 study?

NCT02354677 studies Heathy Volunteers, Smokers, COPD.

Is NCT02354677 still recruiting?

NCT02354677 is currently completed. Last updated 24 September 2019.

Last reviewed 2019-09-24 · How we verify

NCT02354677: RRR

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Repair, Remodeling and Regeneration of the Bronchial Epithelium of COPD Patients

Completed NA Last updated 24 September 2019

What this trial tests

NA trial testing In vitro experiments on bronchial epithelial cells in Heathy Volunteers in 30 participants. Completed in 17 April 2018.

Timeline

17 October 2014

Primary endpoint
17 April 2018

17 April 2018

Quick facts

Lead sponsor	University Hospital, Montpellier
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	basic science
Enrollment	30
Start date	17 October 2014
Primary completion	17 April 2018
Estimated completion	17 April 2018
Sites	1 location across France

Drugs / interventions tested

In vitro experiments on bronchial epithelial cells

Conditions studied

Heathy Volunteers — all drugs for Heathy Volunteers →
Smokers — all drugs for Smokers →
COPD — all drugs for COPD →

Sponsor

University Hospital, Montpellier

Who can join

18 and older, any sex, with Heathy Volunteers or Smokers. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

COPD is characterized by exagerated decline FEV1 related to obstructive non reversible airflow. This could be the consequence of structural changes and inflammatory pattern of the bronchial wall. Lesions could lead to normal but also abnormal remodeling specially in COPD including a decrease in Club cells number and function.There is no treatment actually available targeted to a normal repair of the epithelium. The objective of this work is to identify potential targets for reprograming bronchial epithelial cells I order to achieve a good repair.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Epithelial ciliated beating cells essential for ex vivo ALI culture growth.
Gras D, Petit A, Charriot J, Knabe L, et al · · 2017 · cited 26× · PMID 28468615 · DOI 10.1186/s12890-017-0423-5
The Transcriptome Landscape of the In Vitro Human Airway Epithelium Response to SARS-CoV-2.
Assou S, Ahmed E, Morichon L, Nasri A, et al · · 2023 · cited 13× · PMID 37569398 · DOI 10.3390/ijms241512017
Human airway ex vivo models: new tools to study the airway epithelial cell response to SARS-CoV-2 infection
Assou S, Ahmed E, Morichon L, Nasri A, et al · · 2023 · DOI 10.1101/2023.04.15.536998

Verify or expand the search:

Other University Hospital, Montpellier trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02354677 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Montpellier
Last refreshed: 24 September 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02354677.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing