NCT02339389: matvent

Does Maternal Fever During Labor Analgesia Has Any Relationship With Maternal Ventilation?

Completed Results posted Last updated 19 March 2018

What this trial tests

trial testing Labor analgesia in Pregnancy in 57 participants. Completed in 2 September 2016.

Timeline

14 August 2014

Primary endpoint
2 September 2016

2 September 2016

Quick facts

Lead sponsor	Brigham and Women's Hospital
Status	Completed
Study type	OBSERVATIONAL
Enrollment	57
Start date	14 August 2014
Primary completion	2 September 2016
Estimated completion	2 September 2016
Sites	1 location across United States

Drugs / interventions tested

• Labor analgesia

Conditions studied

• Pregnancy — all drugs for Pregnancy →

Sponsor

Brigham and Women's Hospital

Who can join

Adults 18 to 40, female only, with Pregnancy. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Changes in Maternal Ventilation During Labor Analgesia Primary · Ventilation parameters measured at 2 hour and 4 hour

If Maternal Ventilation decreases following labor analgesia at 2 hour and 4 interval

Maternal ventilation at baseline

Group	Value	95% CI
Study Group	15.3	± 1

Maternal ventilation at 2 hours

Group	Value	95% CI
Study Group	12.6	± 1.1

Maternal Ventilation at 4 hor

Group	Value	95% CI
Study Group	13.8	± 1.2

If Maternal Temperature Increases During Labor Analgesia Secondary · 4 hours

If maternal temperature increases during labor analgesia

baseline temperature

Group	Value	95% CI
Ventilation During Labor Analgesia	98.1	± 0.4

Temperature at 4 hour

Group	Value	95% CI
Ventilation During Labor Analgesia	98.7	± 0.5

Sponsor's own description

Epidural techniques offer the advantage of being able to titrate the level, density, and duration of the blockade through the use of a catheter and are associated with relative maternal hemodynamic stability. One of the disadvantages, however, include a raise in maternal temperature that is attributed to labor epidural technique. This study will assess if decreased maternal ventilation following induction of labor analgesia causes a raise in temperature.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Use of a novel non-invasive respiratory monitor to study changes in pulmonary ventilation during labor epidural analgesia.
   Kodali BS, Choi L, Chau A, Harvey BC, et al · · 2020 · cited 5× · PMID 31286333 · DOI 10.1007/s10877-019-00349-1